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Thioethers

Organosulfur compounds that contain a carbon atom bonded to a sulfur atom that is bonded to a carbon atom in the following structure: C-S-C. Thioethers are considered the sulfur analog of the ether functional group.

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Medchemexpress LLC 3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]- | 2765218-56-0 | 99.1% | C16H15N3O2S | 25 MG
SDP

PY-60 is a robust and specific activator of YAP transcriptional activity that targets annexin A2 (ANXA2) with a Kd of 1.4 μM. It directly binds to ANXA2 and antagonizes its normal cellular function of repressing YAP activity, leading to increased levels of YAP-controlled transcripts in various cell lines. It can also activate a proproliferative, YAP-dependent transcriptional program in adult animals.

  • Activates YAP transcriptional activity
  • Targets annexin A2 (ANXA2) with a Kd of 1.4 μM
  • Directly binds to ANXA2 and antagonizes its normal function
  • Increases levels of YAP-controlled transcripts (ANRKD1, CYR61, and CTGF)
  • Promotes nuclear localization of YAP
  • Can remodel the epidermis through proliferation in adult animals

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