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Organosulfur compounds that have a thiocarbonyl functional group bonded to a nitrogen atom at each side and each nitrogen is bonded to a carbon atom; they are structurally similar to urea, except that the oxygen atom is replaced by a sulfur atom.
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Chemical. CAS 81213-52-7. Formula C10H18NO3S2. MW 264.3. Highly reactive, thiol-specific spin-label. Specific conformational probe of thiol site structure by its minimal rotational freedom and distance from the covalent disulfide linkage to the macromolecule under study. Used to label cysteine residues in proteins site-directed labeling, SDS-labeling. Allows protein structure and protein dynamics determination as well as the study of protein-protein and protein-oligonucleotide interactions.
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