Flavonoids
Apexbio Technology LLC AMG 487 473719-41-4 50mg
AMG 487 (CAS 473719-41-4) is a selective small molecule antagonist targeting chemokine receptor CXCR3 a G protein-coupled receptor involved in immune cell migration It competitively inhibits CXCR3 binding to its cognate chemokines including IP-10 and ITAC with IC50 values reported at approximately 8 nM and 8 2 nM respectively Cell-based assays indicate AMG 487 can effectively impede IP-10 ITAC and MIG-mediated chemotaxis and ITAC-induced calcium mobilization AMG 487 is metabolized via CYP3A4 and CYP3A5 to metabolites one of which (M2) inhibits CYP3A Given these characteristics AMG 487 provides a valuable pharmacological tool for investigating CXCR3 functions in inflammatory and immunological research
Medchemexpress LLC Flavanone | 487-26-3 | 1 ML
Flavanone is a naturally occurring flavone with inhibitory activity for human estrogen synthetase (aromatase) and acts as an inhibitor for the ERK/p38/NF-κB signaling pathway. It exhibits oral activity and antitumor efficacy, demonstrating its potential in various biological processes.
- Inhibits cell proliferation, migration, and invasion of A549 cells
- Arrests cell cycle at G1 phase in vitro
- Inhibits expression of MMP-2, u-PA, cyclin D1, and CDK2
- Promotes generation of TIMP-2 and PAI-1
- Exhibits antitumor efficacy in C57BL/6J mouse models
- Limits tumor growth and inhibits metastasis of LLC cells in vivo
Apexbio Technology LLC Luteolin 491-70-3 10mM (in 1mL DMSO)
Luteolin (CAS 491-70-3) is a naturally occurring flavonoid characterized by anti-inflammatory antioxidant and chemopreventive properties Mechanistically it suppresses lipopolysaccharide (LPS)-mediated inflammation by inhibiting production of pro-inflammatory cytokines such as TNF- and IL-6 reducing inducible nitric oxide synthesis and blocking NF- B and AP-1 signaling pathways Additionally luteolin impedes TNF- -induced cyclooxygenase-2 (COX-2) expression In preclinical in vivo studies it exhibits antiproliferative activity against tumor cell proliferation exemplified by growth inhibition in Lewis lung carcinoma models Consequently luteolin is widely investigated in biomedical research targeting inflammation oxidative stress and cancer biology
Medchemexpress LLC HY-N0423 100mg Medchemexpress, Sophoricoside CAS:152-95-4 Purity:>98%
Medchemexpress, HY-N0423 100mg Sophoricoside CAS:152-95-4 Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Acacetin-7-O-β-D-galactopyranoside | 80443-15-8 | 98.6% | 446.40 | C22H22O10 | 5mg
Acacetin-7-O- -D-galactopyranoside is a flavonoid that can be isolated from flower heads of Chrysanthemum morifolium Acacetin-7-O- -D-galactopyranoside inhibits AChE activity and can be used for research of Alzheimer s disease[1]
TARGETMOL CHEMICALS INC CHRYSIN-7-O-GLUCURONIDE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Chrysin-7-O-glucuronide (Chrysin 7-O-beta-D-glucopyranuronoside) is a natural product with antioxidant activitypurity: 99%
Medchemexpress LLC Hesperetin 7-O-glucoside | 31712-49-9 | MFCD20275042 | 99.4% | 464.4 g/mol | C22H24O11 | 100MG
Hesperetin 7-O-glucoside is a flavanone O-glucoside used in research for its anti-inflammatory, antihypertensive, and antibacterial properties; it has reported activity against digestive enzymes and lipid-regulating targets and is provided as a research reagent.
- Flavanone O-glucoside with molecular formula C22H24O11.
- Molecular weight 464.4 g/mol.
- High purity (99.4% by HPLC).
- Reported inhibition: intestinal maltase (Ki 1.8 mM) and HMG-CoA reductase (Ki 9.8 μM).
- Storage: store at 4°C; in solution store at -80°C (6 months) or -20°C (1 month), protected from light.
- Supplied for research use only; not validated for clinical use.
Selleck Chemical LLC Acacetin S5318-1g
Acacetin (Linarigenin 5 7-dihydroxy-4 -methoxyflavone 4 -Methoxyapigenin) is a flavonoid compound that has been shown to have anti-cancer anti-mutagenic anti-inflammatory and anti-peroxidative effects
Medchemexpress LLC Apigenin-7-glucuronide | 29741-09-1 | 446.36 | 1 MG
Apigenin-7-glucuronide is a compound that inhibits Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, and 0.27 μM for MMP-3, MMP-8, MMP-9, and MMP-13, respectively. This product is for research use only.
- Inhibits matrix metalloproteinases (MMPs)
- Effective against MMP-3, MMP-8, MMP-9, and MMP-13
- Soluble in DMSO up to 250 mg/mL