Flavonoids
Medchemexpress LLC AST 487 | 630124-46-8 | 98.9% | 529.56 | 25 MG
AST 487 is a potent RET kinase inhibitor with an IC50 of 880 nM, and also demonstrates inhibitory activity against Flt-3 with an IC50 of 520 nM. It effectively inhibits RET autophosphorylation and the activation of downstream effectors, making it suitable for studies on human thyroid cancer cell lines with activating RET mutations.
- Inhibits RET kinase (IC50 880 nM)
- Inhibits Flt-3 (IC50 520 nM)
- Targets other kinases including KDR, Flt-4, c-Kit, and c-Abl
- Potently inhibits growth of human thyroid cancer cell lines with activating RET mutations
- Functions as a novel, mutant FLT3 inhibitor
- Inhibits cellular proliferation in FLT3-ITD-Ba/F3 and D835Y-Ba/F3 cells (IC50 less than 5 nM)
Medchemexpress LLC Catechin | 154-23-4 | 290.27 | 5 MG
Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
- 15+ Cited publications
- Also known as (+)-Catechin; Cianidanol; Catechuic acid
- Targeting COX apoptosis, influenza virus, and endogenous metabolite pathways
- Research area: Cancer
- Structural classification: Anti-aging, Camellia sinensis (L.) O. Ktze. plants, endogenous metabolite, flavonoids, sunscreen, flavanols, phenols, polyphenols
- Application fields: Cosmetic research, disease research fields
- Source classification: Theaceae
Medchemexpress LLC Gallocatechin gallate | 5127-64-0 | 1 MG
Gallocatechin gallate is a flavonoids product that can be isolated from the herbs of Celastrus orbiculatus. It is intended for research use only.
- Molecular weight: 458.37
- Formula: C22H18O11
- Appearance: Solid
- Color: White to off-white
- Purity: 98%
- Storage: -20°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light).
- Structure classification: Flavonoids
- Initial source: Plants, celastraceae, celastrus, Celastrus orbiculatus Thunb.
Medchemexpress LLC Rutin (trihydrate) | 250249-75-3 | ≥97.0% | 664.56 | 1 G
Rutin trihydrate is a multifunctional natural flavonoid glycoside. It has demonstrated excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties, as well as cardioprotective and neuroprotective activities.
- Decreases acrylamide-induced cytotoxicity
- Modifies cognitive and behavioral symptoms of neurodegenerative diseases
- Antioxidant properties
- Anti-inflammatory properties
- Anti-diabetic properties
- Anti-carcinogenic properties
- Cardioprotective activities
- Neuroprotective activities
Medchemexpress LLC Myricetin | 529-44-2 | C15H10O8 | 200 MG
Myricetin is a plant-derived flavonoid known for its strong antioxidant, anticancer, antidiabetic, and anti-inflammatory properties. It exhibits diverse cellular effects, including radical scavenging activity and the ability to modulate various signaling pathways, making it suitable for a wide range of research applications.
- Exhibits scavenging activity against various radicals and ions.
- Prevents cancer cell death by apoptosis through regulation of PI3K/Akt and MAPK signaling pathways.
- Displays antiphotoaging effects by quenching free radicals in the skin and suppressing UVB-induced COX-2 expression.
- Inhibits human Hsp70 with notable IC50 values.
- Causes inhibition of rabbit platelet aggregation induced by ADP, arachidonic acid, collagen, and PAF.
Medchemexpress LLC -Catechin hydrate 250mg
( )-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1 4 M
Apexbio Technology LLC (+)-Catechin hydrate 225937-10-0 10mM (in 1mL DMSO)
( )-Catechin hydrate (CAS 225937-10-0) is a plant-derived flavonoid recognized for its antioxidant properties It functions primarily as a free radical scavenger mitigating oxidative stress by neutralizing reactive oxygen species At physiological pH ( )-catechin hydrate has been shown to protect against DNA strand breaks induced by hydroxyl radicals indicating its capacity to prevent free radical-mediated cellular damage This compound is widely utilized in biomedical research to investigate cellular defense mechanisms against oxidative injury and to explore potential therapeutic strategies for conditions associated with oxidative stress
Apexbio Technology LLC Catechin 154-23-4 50mg
Catechin (154-23-4) is a small-molecule inhibitor targeting cyclooxygenase-1 (COX-1) It is designed to inhibit COX-1 activity thereby modulating inflammation-related pathways Catechin exerts its biological activity primarily through inhibition of COX-1 In cell-based assays catechin demonstrates inhibitory activity with an IC50 value of approximately 1 4 M Based on these pharmacological properties catechin holds research potential in studies of oxidative stress pathways inflammation processes and enzyme inhibition screening
Medchemexpress LLC Catechin (Standard) | 154-23-4 | 290.27 | 50 MG
Catechin (Standard) is an analytical standard intended for research and analytical applications. It inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM and serves as a reference standard assay.
- Used in qualitative research experiments
- Used in quantitative research experiments
- Used in methodological research experiments
- Compatible with HPLC, GC, and MS techniques
Medchemexpress LLC (±)-Catechin | 7295-85-4 | 99.5% | 100 MG
(±)-Catechin (rel-Cianidanol) is the racemate of the green tea polyphenol Catechin. Catechin has anticancer activity and induces apoptosis. It has two forms, (+)-Catechin and its enantiomer (-)-Catechin, each with distinct biological activities. The racemate exhibits anti-tumor, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious, hepatoprotective, and neuroprotective effects.
- Racemate of green tea polyphenol Catechin.
- Has anticancer activity and induces apoptosis.
- (+)-Catechin form inhibits cyclooxygenase-1 (COX-1).
- (-)-Catechin form promotes hBM-MSC adipocyte differentiation.
- Possesses anti-tumor, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious, hepatoprotective, and neuroprotective effects.
- Appearance: Solid, White to off-white.
- Solubility: In Vitro: DMSO : 100 mg/mL.
Medchemexpress LLC Rutin trihydrate | 250249-75-3 | ≥97.0% | 664.56 | 50 MG
Rutin (Rutoside) trihydrate is a multifunctional natural flavonoid glycoside. It has demonstrated excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties. It also exhibits cardioprotective and neuroprotective activities.
- Multifunctional natural flavonoid glycoside
- Excellent antioxidant properties
- Anti-inflammatory properties
- Anti-diabetic properties
- Anti-carcinogenic properties
- Cardioprotective activities
- Neuroprotective activities
Medchemexpress LLC (-)-epigallocatechin gallate | 989-51-5 | MFCD00075940 | 98.1% | C22H18O11 | 10MG
(-)-Epigallocatechin gallate (EGCG) is a flavonoid phenol supplied as a high-purity analytical reference standard for chromatography and mass spectrometry. It is provided as a solid for research applications; users should follow the certificate of analysis for storage and handling.
- Analytical standard for HPLC, GC, and MS method development and quantitation.
- High purity: 98.1% (rounded from COA).
- Chemical formula C22H18O11; molecular weight 458.37 g/mol.
- Available in small package sizes suitable for analytical assays.
- Physical appearance: white to off-white solid.
- Intended for research use only; not for human or clinical use.