Flavonoids
Medchemexpress LLC AMG 487 (S-enantiomer) | 473720-30-8 | C32H28F3N5O4 | 5 MG
AMG 487 S-enantiomer is the S enantiomer of AMG 487. It functions as an antagonist of the chemokine receptor CXCR3. This product is intended for research use only and is not sold to patients.
- Antagonist of chemokine receptor CXCR3.
- High purity (99.94%).
- Solid appearance.
- Off-white to light yellow color.
- Recommended storage conditions for powder and in solvent.
Apexbio Technology LLC AST 487 630124-46-8 5mg
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Apexbio Technology LLC AST 487 630124-46-8 10mg
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Cayman Chemical SalvIa plebeIa npItrIn 1mg
A flavonoid glycoside with diverse biological activities; protects lard from thermal oxidation at 0.02 and 0.04%; inhibits carrageenin-induced edema and yeast-induced fever in rats; decreases serum levels of triglycerides and LDL, as well as increases serum HDL levels, in a rat model of high-fat diet-induced atherosclerosis at 20 and 50 mg/kg
TARGETMOL CHEMICALS INC HYPEROSIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Hyperoside (Hyperin) is a naturally occuring flavonoid compound which shows multiple bioactivities including myocardial protection anti-redox and anti-inflammatory activities. purity: 99%
Apexbio Technology LLC Naringin 10236-47-2 10g
Naringin (CAS 10236-47-2) is a flavanone glycoside predominantly isolated from the fruit of Citrus paradisi Macfadyen (grapefruit) It is recognized for modulating various cellular pathways including inhibition of oxidative stress and inflammation through interaction with NF- B and MAPK signaling cascades Naringin has demonstrated antioxidative anti-inflammatory and potential anti-carcinogenic properties in cellular and animal models Widely used in biomedical research it serves as a tool compound for investigating mechanisms underlying chronic diseases metabolic syndromes and the modulation of drug-metabolizing enzymes For optimal stability it should be stored in a tightly sealed container under cool dry conditions
Sigma Aldrich Fine Chemicals Biosciences Naphthol AS-MX Phosphate | 1596-56-1 | MFCD00042711 | 20ml
Naphthol AS-MX Phosphate | Mol Wt: 371.32 | 1596-56-1 | MFCD00042711 | 20ml
Medchemexpress LLC 3′-hydroxyflavanone | 92496-65-6 | MFCD00017738 | >=98.0% | 240.25 g/mol | C15H12O3 | 250 MG
3′-Hydroxyflavanone is a cyclized flavanone research compound reported to induce apoptosis in HeLa cells and to possess antitumor activity. It is supplied as a solid for research use and is characterized by its molecular formula and reported physicochemical properties.
Apexbio Technology LLC (±)-AMG 487 10mg
racemic Baclofen -AMG 487 is a small-molecule antagonist targeting the chemokine receptor CXCR3 It is designed to inhibit ligand-induced CXCR3-mediated immune cell migration thereby modulating lymphocyte recruitment to inflammatory and metastatic sites racemic Baclofen -AMG 487 exerts its biological activity primarily through selective inhibition of CXCR3-mediated cell migration In in vitro studies racemic Baclofen -AMG 487 demonstrates inhibition of ligand-induced CXCR3-dependent cell movement Based on these pharmacological properties racemic Baclofen -AMG 487 holds research potential in inflammation and oncology studies
TARGETMOL CHEMICALS INC SAKURANETIN 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Sakuranetin a flavanone phytoalexin from ultraviolet-irradiated rice leaves it has antifungal antimutagenic anti-inflammatory and antioxidant effectspurity: 99%
Medchemexpress LLC AMG 487 | 473719-41-4 | C32H28F3N5O4 | 100 MG
AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3). It inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
- Targets CXCR3
- Involved in GPCR/G Protein and immunology/inflammation pathways
- Inhibits CXCR3-mediated cell migration
- Inhibits calcium mobilization
- Leads to fewer lung metastases
- Reduces tumor volume