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Polyphenolic organic compounds that have 15 carbons with the general structure of two phenyl rings and a heterocyclic ring, or a ring with two or more atoms. Flavonoids are a class of polyphenolic plant and fungus secondary metabolites.
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Icariin (CAS 489-32-7) is a small-molecule inhibitor targeting phosphodiesterases notably PDE5 and PDE4 It is designed to modulate cyclic nucleotide signaling by inhibiting PDE activity thereby regulating processes such as smooth muscle relaxation and neuronal signaling Icariin exerts its biological activity primarily through the inhibition of PDE5 (IC 0 43 M) and PDE4 (IC 73 50 M) Based on these pharmacological properties icariin holds research potential in the investigation of erectile function nitric oxide synthase expression angiogenesis pathways and osteogenic differentiation in bone marrow stromal cells
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