Linear 1 3-diarylpropanoids
Medchemexpress LLC Avobenzone | 70356-09-1 | 98.0% | 10 MM 1 ML
Avobenzone is a dibenzoylmethane compound that is widely used as a filter in sunscreens for skin photoprotection in the UVA band. It is also identified as an endocrine disruptor that directly binds to estrogen receptor β and functions as an estrogen agonist.
- Long-Wave UVA Filter.
- Significantly promotes adipogenesis in hBM-MSCs at an EC50 of 14.1 μM.
- Up-regulates mRNA levels of PPARγ during adipogenesis in hBM-MSCs at 10 μM.
- Inhibits proliferative activities of human trophoblast cells and induces apoptosis in HTR8/SVneo cells at concentrations of 1-50 μM over 48 hours.
- Exhibits weak ERα agonism and weak AR antagonism.
Medchemexpress LLC 1,3-Propanedione, 1,3-diphenyl- | 120-46-7 | 98.0% | 224.26 | 1 ML
Dibenzoylmethane is a minor ingredient in licorice that activates Nrf2, playing a role in preventing various cancers and oxidative damage. It acts as an analog of curcumin, causing dissociation from Keap1 and nuclear translocation of Nrf2. It is provided for research use only.
- Activates Nrf2 pathway
- Analog of curcumin
- Prevents cancers and oxidative damage
- Increases HO-1 and Nrf2 protein expression
- Protects against CCl4-induced liver damage in wild-type mice
Apexbio Technology LLC Avobenzone 70356-09-1 10mM (in 1mL DMSO)
Avobenzone (70356-09-1) is a small-molecule agonist targeting estrogen receptor (ER ) It is designed to bind directly to ER thereby modulating endocrine signaling pathways Avobenzone exerts its biological activity primarily through direct receptor binding and estrogenic agonist activity Based on these properties Avobenzone holds research potential in studies investigating endocrine-disrupting chemicals mechanisms of photoprotection UV-induced cellular damage and skin pathology
Medchemexpress LLC Xanthohumol C | 189299-05-6 | 99.2% | 352.38 | C21H20O5 | 10 MG
Xanthohumol C is a prenylchalcone natural product isolated from the hops plant Humulus lupulus. It is used in research and has reported cytotoxic and antiproliferative activity in human cancer cell lines.
- Chemical formula C21H20O5.
- Molecular weight 352.38.
- Purity 99.2%.
- Reported cytotoxicity against HeLa cells (IC50 12.5 μM).
- Antiproliferative activity against MCF7 cells (IC50 15.7 μM for 2 days, 6.87 μM for 4 days).
- Supplied as a 10 MG research quantity.
Medchemexpress LLC Xanthohumol C | 189299-05-6 | 352.38 | 5 MG
Xanthohumol C is a prenylchalcone that can be isolated from the hops of Humulus lupulus. It is categorized as a natural compound with a molecular weight of 352.38 and a chemical formula of C21H20O5. This compound appears as a light yellow to yellow solid and is intended for research use only, not for sale to patients.
- It is a prenylchalcone, a type of natural compound.
- It can be isolated from the hops of Humulus lupulus.
- It exhibits cytotoxicity against human HeLa cells with an IC50 of 12.5 μM.
- It shows antiproliferative activity against human MCF7 cells with IC50 values of 15.7 μM (2 days) and 6.87 μM (4 days).
Medchemexpress LLC Xanthohumol D | 274675-25-1 | 370.40 | 5 MG
Xanthohumol D, isolated from hops, is an inhibitor of quinone reductase-2 (QR-2) with an IC50 value of 110 μM, and binds to the active site of QR-2. It shows antiproliferative activity on human cancer cell lines in vitro.
- Inhibitor of quinone reductase-2 (QR-2) with an IC50 value of 110 μM
- Binds to the active site of QR-2
- Exhibits antiproliferative activity on human cancer cell lines in vitro
Medchemexpress LLC Xanthohumol | 6754-58-1 | 99.9% | 354.40 | 5 MG
Xanthohumol is a principal flavonoid isolated from hops. It inhibits diacylglycerol acetyltransferase (DGAT), COX-1, and COX-2, and demonstrates anti-cancer, anti-angiogenic, and antiviral activities against viruses like bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2, and cytomegalovirus (CMV).
- Derived from hops
- Inhibits diacylglycerol acetyltransferase (DGAT)
- Inhibits COX-1 and COX-2
- Exhibits anti-cancer activity
- Exhibits anti-angiogenic activity
- Possesses antiviral activity
- Classified as a flavonoid, chalcone, phenol, and polyphenol
Selleck Chemical LLC Xanthohumol
Xanthohumol a prenylated chalcone from hop inhibits COX-1 and COX-2 activity and shows chemopreventive effects Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 M Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses Xanthohumol induces growth inhibition and apoptosis in cancer cells Phase 1
Medchemexpress LLC Phlorizin | 60-81-1 | 99.9% | 436.41 | 5 G
Phlorizin is a non-selective SGLT inhibitor that acts on hSGLT1 and hSGLT2. It also functions as a Na+/K+-ATPase inhibitor.
- Non-selective SGLT inhibitor.
- Inhibits hSGLT1 and hSGLT2.
- Na+/K+-ATPase inhibitor.
- Decreases blood glucose levels.
- Prevents nerve fiber decrease and retinal abnormalities.
Selleck Chemical LLC Phloretin (RJC 02792) S2342-10mM/1mL
Phloretin (RJC 02792 NSC 407292 Dihydronaringenin) is a dihydrochalcone found in apple tree leaves which shows beneficial effects on diabetes