Macrolide lactams
Apexbio Technology LLC FK 866 hydrochloride(Synonyms: FK866 hydrochloride, APO866 hydrochloride, Daporinad hydrochloride), 5mg, CAS: 658084-64-1 (free base).
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models
Apexbio Technology LLC FK 866 hydrochloride(Synonyms: FK866 hydrochloride, APO866 hydrochloride, Daporinad hydrochloride), 25mg, CAS: 658084-64-1 (free base).
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models
Apexbio Technology LLC FK 866 hydrochloride(Synonyms: FK866 hydrochloride, APO866 hydrochloride, Daporinad hydrochloride), 50mg, CAS: 658084-64-1 (free base).
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models
Apexbio Technology LLC FK 866 hydrochloride(Synonyms: FK866 hydrochloride, APO866 hydrochloride, Daporinad hydrochloride), 10mg, CAS: 658084-64-1 (free base).
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models
Apexbio Technology LLC FK 866 hydrochloride(Synonyms: FK866 hydrochloride, APO866 hydrochloride, Daporinad hydrochloride), 10mM (in 1mL DMSO), CAS: 658084-64-1 (free base).
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models
Medchemexpress LLC Tacrolimus 8-epimer | 129212-35-7 | MFCD27967171 | 10mg
Tacrolimus anhydrous 8-epimer (Tacrolimus EP impurity D) is a l-pipecolic acid macrolide lactone an important immunosuppressive agent that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines especially IL-2[1]
Medchemexpress LLC Tacrolimus 8-epimer | 129212-35-7 | MFCD27967171 | 5mg
Tacrolimus anhydrous 8-epimer (Tacrolimus EP impurity D) is a l-pipecolic acid macrolide lactone an important immunosuppressive agent that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines especially IL-2[1]
Apexbio Technology LLC Ascomycin(FK 520) 104987-12-4 100mg
Ascomycin FK 520 (CAS 104987-12-4) is a small-molecule immunosuppressant targeting calcineurin phosphatase via binding to immunophilin FKBP12 It is designed to inhibit calcineurin activity thereby suppressing NFAT-mediated T-cell activation and proliferation Ascomycin FK 520 exerts its biological activity primarily by forming a complex with FKBP12 that inhibits calcineurin phosphatase In in vitro assays Ascomycin FK 520 demonstrates dose-dependent inhibition of lymphocyte responsiveness with an IC50 in the submicromolar range and no cytotoxicity observed below 3 2 M In animal models administration at doses 3 2 mg/kg prolongs skin transplant survival in rats Based on these pharmacological properties Ascomycin FK 520 holds research potential in studies of calcineurin-mediated immune responses and the development of T-cell modulation strategies
Apexbio Technology LLC Ascomycin(FK 520) 104987-12-4 50mg
Ascomycin FK 520 (CAS 104987-12-4) is a small-molecule immunosuppressant targeting calcineurin phosphatase via binding to immunophilin FKBP12 It is designed to inhibit calcineurin activity thereby suppressing NFAT-mediated T-cell activation and proliferation Ascomycin FK 520 exerts its biological activity primarily by forming a complex with FKBP12 that inhibits calcineurin phosphatase In in vitro assays Ascomycin FK 520 demonstrates dose-dependent inhibition of lymphocyte responsiveness with an IC50 in the submicromolar range and no cytotoxicity observed below 3 2 M In animal models administration at doses 3 2 mg/kg prolongs skin transplant survival in rats Based on these pharmacological properties Ascomycin FK 520 holds research potential in studies of calcineurin-mediated immune responses and the development of T-cell modulation strategies
Apexbio Technology LLC Ascomycin(FK 520) 104987-12-4 10mM (in 1mL DMSO)
Ascomycin FK 520 (CAS 104987-12-4) is a small-molecule immunosuppressant targeting calcineurin phosphatase via binding to immunophilin FKBP12 It is designed to inhibit calcineurin activity thereby suppressing NFAT-mediated T-cell activation and proliferation Ascomycin FK 520 exerts its biological activity primarily by forming a complex with FKBP12 that inhibits calcineurin phosphatase In in vitro assays Ascomycin FK 520 demonstrates dose-dependent inhibition of lymphocyte responsiveness with an IC50 in the submicromolar range and no cytotoxicity observed below 3 2 M In animal models administration at doses 3 2 mg/kg prolongs skin transplant survival in rats Based on these pharmacological properties Ascomycin FK 520 holds research potential in studies of calcineurin-mediated immune responses and the development of T-cell modulation strategies
Medchemexpress LLC FK 3311 | 116686-15-8 | MFCD00876455 | 98.7% | C15H13F2NO4S | 50 MG
FK 3311, also known as COX-2 Inhibitor V, is a selective inhibitor of COX-2 with anti-inflammatory properties. It is intended for research use only.
- Targets COX-2
- Exhibits anti-inflammatory activity by inhibiting adjuvant-induced arthritis
- Demonstrates analgesic effects in the acetic acid-induced writhing assay
- Improves L-PVR, CO, PaO(2), and WDR in a canine model of pulmonary ischemia-reperfusion injury
- Reduces histological tissue edema and PMN infiltration
- Lowers serum TxB(2) levels and improves survival rate in pulmonary ischemia-reperfusion injury
- Improves survival rates and lowers serum GOT/GPT levels in liver transplantation with ischemia-reperfusion injury