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Organic compounds characterized by having a lactone ring (14–16 atoms) bonded to one or more deoxy sugar molecules; they are a class of closely related antibiotics. Analogues (compounds with similar structure) are included.
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Epothilone B is a microtubule stabilizer (MSA) with a Ki of 0.71μM and possesses blood-brain barrier permeability. It functions by binding to the αβ-tubulin heterodimer subunit, which leads to a decrease in αβ-tubulin dissociation. It is intended for research use only and is not sold to patients.
Microtubule stabilizer (MSA)
Blood-brain barrier permeability
Binds to the αβ-tubulin heterodimer subunit
Decreases αβ-tubulin dissociation
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