Choose the brand aligned with your industry so we can best serve your needs.
For researchers, scientists, and technical professionals: Your one-stop shop for the complete range of laboratory, production, and safety products and services.
Transition metal salts are ionic compounds formed with transition metal cations. They are available in a variety of chemical compositions, quantities, purities, and reagent grades and possess magnetic and catalytic properties.
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
AGI-41998 is a potent and orally active inhibitor of methionine adenosyltransferase 2A (MAT2A) that effectively penetrates the blood-brain barrier. It exhibits significant inhibitory activities against MAT2A and S-adenosyl methionine (SAM) in HCT-116 MTAP-null cells. This compound can significantly inhibit HCT-116 cell proliferation and tumor growth, making it useful for studying SAM regulation in the central nervous system and colon cancer.
Potent and orally active MAT2A inhibitor
Effectively penetrates the blood-brain barrier
Exhibits inhibitory activity against MAT2A and S-adenosyl methionine (SAM)
Significantly inhibits HCT-116 cell proliferation
Inhibits tumor growth in xenograft models
Reduces tumor and brain SAM levels
Decreases SAM levels in tumors by approximately 80%
No significant weight loss observed in animal models
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More