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Medchemexpress LLC Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)ami | 2377492-26-5 | 99.9% | C22H16BrF3N4O2 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY14577810MM/1ML

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AGI-41998 is a potent and orally active inhibitor of methionine adenosyltransferase 2A (MAT2A) that effectively penetrates the blood-brain barrier. It exhibits significant inhibitory activities against MAT2A and S-adenosyl methionine (SAM) in HCT-116 MTAP-null cells. This compound can significantly inhibit HCT-116 cell proliferation and tumor growth, making it useful for studying SAM regulation in the central nervous system and colon cancer.

  • Potent and orally active MAT2A inhibitor
  • Effectively penetrates the blood-brain barrier
  • Exhibits inhibitory activity against MAT2A and S-adenosyl methionine (SAM)
  • Significantly inhibits HCT-116 cell proliferation
  • Inhibits tumor growth in xenograft models
  • Reduces tumor and brain SAM levels
  • Decreases SAM levels in tumors by approximately 80%
  • No significant weight loss observed in animal models

Catalog No. 50-003-54336


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