Phenols
Medchemexpress LLC 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) | 1197033-19-4 | 98.6% | 899.97 | 100 MG
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer for synthesizing locked nucleic acid (LNA) analog oligonucleotides. It acts as a building block for antisense oligonucleotides (ASOs), targeting complementary RNA sequences. This compound features a 2',4'-constrained ethyl (cEt) modification, which enhances hybridization affinity, improves mismatch discrimination with RNA, and significantly increases resistance to exonuclease digestion. It mediates RNase H-dependent mRNA degradation or inhibits translation by forming stable hybrids, thereby regulating gene expression.
- Used in antisense drug development and gene therapy.
- Applicable in molecular biology techniques, including PCR and primer extension.
- Aids in gene silencing and small RNA research.
Medchemexpress LLC P 22077 | 1247819-59-5 | 98.42% | 315.32 | 10 MG
P 22077 is a cell-permeable inhibitor targeting ubiquitin-specific protease 7 (USP7) with an EC50 of 8.01 μM, and USP47 with an EC50 of 8.74 μM. This compound demonstrates antiproliferative activity against human HCT116 cells and induces p53-mediated apoptosis in neuroblastoma cells, highlighting its potential for anticancer research.
- Cell-permeable USP7 and USP47 inhibitor
- Inhibits USP7 with an EC50 of 8.01 μM
- Inhibits USP47 with an EC50 of 8.74 μM
- Shows antiproliferative activity against human HCT116 cells
- Induces p53-mediated apoptosis in neuroblastoma cells
- Exhibits antitumor effects in xenograft mouse models
Medchemexpress LLC Tri-p-tolylphosphine | 1038-95-5 | ≥98.0% | 304.37 | 25 G
Tri-p-tolylphosphine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is for research use only and not sold to patients. It is also used as a pharmaceutical intermediate.
- Appearance is solid.
- Color is white to off-white.
- Shipping is at room temperature in continental US; may vary elsewhere.
- Storage is at 4°C, stored under nitrogen. In solvent: -80°C for 6 months; -20°C for 1 month (stored under nitrogen).
Boston Bioproducts Inc BioAcryl-P Acrylamide/Bis-Acrylamide (40%, 39:1) - 500ml
BioAcryl-P Acrylamide/Bis-Acrylamide (40% 39/1) - 500ml (For Research Use and Further Manufacturing Only)
ILEX LIFE SCIENCES LLC HIRUDIN P. PASTORIS REC 10 UG
Ilex Life Sciences Hirudin Recombinant Protein (Pichia pastoris), 10 ug. DESCRIPTION: Our bioactive Hirudin Recombinant protein, expressed in yeast, is a polypeptide chain that contains 65 amino acids and has a 6979.5 Dalton molecular mass. Hirudin Recombinant is identical to natural Hirudin except for the substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63. FORMULATION: Sterile filtered white lyophilized (freeze-dried) powder. The hirudin protein was lyophilized from a sterile solution containing 20mM PBS pH-7 and 2% mannitol. PURITY: Greater than 95.0% as determined by: 1) Analysis by RP-HPLC, and 2) Analysis by SDS-PAGE. BIOLOGICAL ACTIVITY: The specific activity was found to be greater than 14,000 ATU/mg (may vary with each lot; please refer to the enclosed datasheet). USAGE: This product is intended for Laboratory Research Use Only. Not for use in diagnostic or therapeutic procedures.
Medchemexpress LLC 4-hydroxybenzaldehyde-2,3,5,6-d4 | 284474-52-8 | MFCD00190461 | 99.7% | 126.15 g·mol⁻¹ | C7H2D4O2 | 5mg
p-Hydroxybenzaldehyde-d4 is the deuterium labeled p-Hydroxybenzaldehyde p-Hydroxybenzaldehyde is a one of the major components in Dendrocalamus asper bamboo shoots with antagonistic effect on GABAA receptor of the 1 2 2S subtype at high concentrations
Medchemexpress LLC Fibrinogen-Binding Peptide TFA | 99.3% | 679.64 | 10 MG
Fibrinogen-Binding Peptide TFA is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor, designed by the anticomplementarity hypothesis. It binds to fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation, as well as inhibiting the adhesion of platelets to vitronectin. It is intended for research use only.
- Designed by anticomplementarity hypothesis
- Binds fibrinogen
- Inhibits adhesion of platelets to fibrinogen
- Inhibits platelet aggregation
- Inhibits adhesion of platelets to vitronectin
- Intended for research use only
Apexbio Technology LLC Ansamitocin P-3 66547-09-9 5mg
Ansamitocin P-3 (CAS 66547-09-9) is a small-molecule inhibitor targeting tubulin It is designed to disrupt microtubule assembly by potently inhibiting tubulin polymerization thereby affecting cellular processes reliant on microtubule dynamics Ansamitocin P-3 exerts its biological activity primarily through inhibition of tubulin polymerization In cell-based studies Ansamitocin P-3 demonstrates cytotoxicity with IC50 values of approximately 4 10 g/ml in human lung carcinoma A-549 and colon carcinoma HT-29 cells and 2 10 g/ml in breast carcinoma MCF-7 cells Additionally it inhibits ciliary regeneration in Tetrahymena cells at concentrations around 1 M Based on these pharmacological properties Ansamitocin P-3 holds research potential in oncology particularly in studies of microtubule dynamics anticancer drug mechanisms and ciliogenesis
Cambridge Isotope Laboratories p-n-Nonylphenol triethoxylate (unlabeled) 100 ug/mL in nonane 1 2 mL
p-n-Nonylphenol triethoxylate (unlabeled) 100 ug/mL in nonane 1 2 mL
Aobchem 5-Hydroxy-2-methylbenzoic acid, AOBCHEM USA 21532-25G. 578-22-3. MFCD09833184
5-Hydroxy-2-methylbenzoic acid, AOBCHEM USA 21532-25G. 578-22-3. MFCD09833184
Medchemexpress LLC Calmodulin binding peptide 1 | 104041-80-7 | 98.68% | 5301.10 | 10 MG
Calmodulin Binding Peptide 1 is a high-affinity (pM) CaM-binding peptide derived from smooth muscle myosin light chain kinase (MLCK peptide). The interface of the complex formed by Calmodulin Binding Peptide 1 and Ca2+-CaM can be specifically bound by small-molecule inhibitors, serving as a key target for selective regulation of smooth muscle contraction and development of anti-CaM drugs. In vitro, it binds to the human calmodulin fluorescent biosensor hCaM M124C-mBBr with high affinity and can displace the lower-affinity inhibitor MBC from the biosensor.
- High-affinity CaM-binding peptide
- Derived from smooth muscle myosin light chain kinase
- Target for selective regulation of smooth muscle contraction
- Useful for development of anti-CaM drugs
- Binds to human calmodulin fluorescent biosensor with high affinity
Medchemexpress LLC Macrophage migration inhibitory factor (mouse) | 97.0% | 20UG
Recombinant mouse macrophage migration inhibitory factor (MIF) expressed in Pichia pastoris with an N-terminal 6xHis tag. Supplied lyophilized for research use, this protein supports studies of innate immunity, inflammation, enzymatic activity, and receptor interactions, and is formulated for low endotoxin and long-term storage.
- High purity (>97% by reducing SDS-PAGE)
- Low endotoxin (<1 EU/μg) suitable for cell-based assays
- Expressed in Pichia pastoris with N-terminal 6xHis tag
- Lyophilized formulation for long-term storage and stability
- Stable at -20°C; reconstituted stability at 4°C for 1 week
- Includes sequence and UniProt accession P34884 for traceability
Cambridge Isotope Laboratories p-n-Nonylphenol triethoxylate (ring-13C6 99%) 100 ug/mL in nonane 1 2 mL
p-n-Nonylphenol triethoxylate (ring-13C6 99%) 100 ug/mL in nonane 1 2 mL
Medchemexpress LLC P-2281 | 1112994-35-0 | 209.63 | C9H8ClN3O | 10 MG
P-2281 is a small-molecule mTOR inhibitor provided for laboratory research use. It shows reported anticancer and anti-inflammatory activity in preclinical studies, has a molecular weight of 209.63 g/mol, and is highly soluble in DMSO. Store protected from light; in solution, long-term storage at -80°C is recommended.
- Small-molecule inhibitor of mTOR suitable for research applications.
- Soluble in DMSO at high concentration (125 mg/mL; may require ultrasonic assistance).
- Molecular weight 209.63 g/mol for dosing and calculation purposes.
- Stable under recommended storage: short-term at -20°C in solution and long-term at -80°C; protect from light.
- Intended for in vitro and preclinical research use only.
Medchemexpress LLC PfLDH P. falciparum 10ug | 10ug
The pfHPRT (Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase) protein is a member of the LDH/MDH (lactate dehydrogenase/malate dehydrogenase) superfamily It plays a crucial role in the purine metabolism salvage pathway of the malaria-causing parasite Plasmodium falciparum PfLDH Protein P falciparum (His) is the recombinant PfLDH protein expressed by E coli with C-His labeled tag