Phenols
Apexbio Technology LLC Ansamitocin P-3 66547-09-9 10mM (in 1mL DMSO)
Ansamitocin P-3 (CAS 66547-09-9) is a small-molecule inhibitor targeting tubulin It is designed to disrupt microtubule assembly by potently inhibiting tubulin polymerization thereby affecting cellular processes reliant on microtubule dynamics Ansamitocin P-3 exerts its biological activity primarily through inhibition of tubulin polymerization In cell-based studies Ansamitocin P-3 demonstrates cytotoxicity with IC50 values of approximately 4 10 g/ml in human lung carcinoma A-549 and colon carcinoma HT-29 cells and 2 10 g/ml in breast carcinoma MCF-7 cells Additionally it inhibits ciliary regeneration in Tetrahymena cells at concentrations around 1 M Based on these pharmacological properties Ansamitocin P-3 holds research potential in oncology particularly in studies of microtubule dynamics anticancer drug mechanisms and ciliogenesis
TARGETMOL CHEMICALS INC SKLB1002 25MG
Also available in 1 mg 2 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SKLB1002 is a potent and ATP-competitive VEGFR2 inhibitor with IC50 of 32 nM. purity: 99%
eMolecules 3,4-Dimethylphenol | Oakwood Chemical | 95-65-8 | MFCD00002304 | 122.167 | C8H10O | 99.000 | Cc1ccc(O)cc1C | 100g | 600900026
3,4-Dimethylphenol | Oakwood Chemical | 95-65-8 | MFCD00002304 | 122.167 | C8H10O | 99.000 | Cc1ccc(O)cc1C | 100g | 600900026
Medchemexpress LLC Polyadenylic acid potassium | 26763-19-9 | MFCD00131937 | 90.0% | (C10H13KN5O7P)n | 50 MG
Polyadenylic acid potassium (Poly(A)) is the potassium salt of a homopolymeric adenylic acid that mimics the poly(A) tail of eukaryotic mRNA. It is used in molecular biology to study mRNA stability, protein-RNA interactions, and small-molecule binding to mRNA tails.
Medchemexpress LLC N-biotinyl p-aminophenyl arsenic acid | 212391-23-6 | MFCD29472395 | 98.1% | 427.35 g/mol | C16H22AsN3O4S | 10mg
N-Biotinyl p-aminophenyl arsenic acid is a bifunctional reagent that can bind to both streptavidin and dithiols N-Biotinyl p-aminophenyl arsenic acid decreases the Rbungarotoxin-binding sites in reduced Torpedo nicotinic receptors (IC50 is 10-300 nM) and protects the receptor from irreversible alkylation by bromoacetylcholine[1]
![eMolecules Pharmablock 3-fluorobicyclo[1 1 1]pentane-1-carboxylic acid 250mg 551107223 PBHM9062 0 000 146038-53-1 MFCD19228680 130 118 C6H7FO2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
eMolecules Pharmablock 3-fluorobicyclo[1 1 1]pentane-1-carboxylic acid 250mg 551107223 PBHM9062 0 000 146038-53-1 MFCD19228680 130 118 C6H7FO2
Pharmablock 3-fluorobicyclo[1 1 1]pentane-1-carboxylic acid 250mg 551107223 PBHM9062 0 000 146038-53-1 MFCD19228680 130 118 C6H7FO2
Cayman Chemical Anhydrotetracycline hydrochl
A powerful effector in both the TetR and revTetR transcriptional regulator systems, binding the Tet repressor 35-fold more strongly than Tet; does not act a general inhibitor of translation and is a poor antibiotic
TARGETMOL CHEMICALS INC TNO155 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 0.011 uM)with potential antineoplastic activity. purity: 99%
TARGETMOL CHEMICALS INC MRTX-1257 5MG
Also available in 1mg 2mg 10mg 25mg 50mg 100mg and bulk. Please contact Fisher for quotes. MRTX-1257 is a selective irreversible and covalent inhibitor of KRAS G12C. It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. MRTX1257 demonstrated 31% bioavailability in the mouse with free fraction exposures well above the cellular potency In a PK/PD experiment 77% target engagement. purity: 99%
FUJIFILM BIOSCIENCES INC p-Amidinophenylmethanesulf
p-APMSF is used as a serine protease activity inhibitor Since it specifically suppresses the activity of blood coagulation factor Xa it is used for the study of blood coagulation mechanism Compared to DFP diisopropylfluorophosphate it is easy to handle because it is powder and soluble to water In addition it is reported that serine protease inhibitory activity is several hundred times higher than DFP and PMSF It inhibits the activity of trypsin thrombin plasmin kallikrein and others It does not affect chymotrypsin or acetylcholinesterase For research use only RUO
Apexbio Technology LLC p-Cresyl sulfate potassium 91978-69-7 50mg
p-Cresyl sulfate potassium (CAS 91978-69-7) is the potassium salt form of p-cresyl sulfate a metabolite that accumulates as a protein-bound uremic toxin in patients with chronic kidney disease Biologically it exerts proinflammatory effects by activating cellular signaling pathways including c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) which can enhance inflammatory responses Research indicates that p-cresyl sulfate potassium also contributes to cardiovascular risk by adversely impacting vascular and cardiac function This compound is utilized in experimental studies investigating the molecular mechanisms of uremic toxicity inflammation and cardiorenal syndromes
Medchemexpress LLC (S)-4-(2-(2-bromoacetamido)acetamido)-5-((3-(4-((6aR,6bS,7S,8aS,8bS)-7-hydroxy | 2734878-02-3 | 99.6% | 866.79 | C43H52BrN3O11 | 1 MG
INX-P is a glucocorticosteroid-target antibody drug conjugate (ADC) designed for research use. The compound targets the glucocorticoid receptor and is supplied as a solid with high reported purity and defined physicochemical properties.
- Intended use: research use only, not for human therapeutic use.
- Target: glucocorticoid receptor.
- Form: solid, white to off-white.
- Purity: 99.63% reported by certificate of analysis.
- Molecular weight: 866.79.
- Chemical formula: C43H52BrN3O11.
- CAS number: 2734878-02-3.
- Available pack sizes: 1 MG, 5 MG, 10 MG, larger sizes available by quote.
TARGETMOL CHEMICALS INC SELONSERTIB 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Selonsertib (GS-4997) is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with potential anti-inflammatory antineoplastic and anti-fibrotic activities. purity: 98%
TARGETMOL CHEMICALS INC CAPZIMIN 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11. purity: 98%
TARGETMOL CHEMICALS INC ACSS2-IN-2 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ACSS2-IN-2 (MTB-9655) is an inhibitor of acyl-CoA synthetase short-chain family member 2 (ACSS2). ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-IN-2 can be used for the research of several diseases such as viral infection metabolic disorders neuropsychiatric diseases inflammatory/autoimmune conditions and cancer. purity: 99%