Phenols
Medchemexpress LLC PG 34 | 1681056-62-1 | 98.0% | 547.65 | 1 ML
PG 34 is a weak O-GlcNAc transferase (OGT) inhibitor with an IC50 of 68 μM. It is a structural analog of OSMI-1 and is intended for research use only.
- Weak OGT inhibitor (IC50=68 μM)
- Structural analog of OSMI-1
- Available in solid and solution forms
Medchemexpress LLC Pardoprunox hydrochloride | 269718-83-4 | 99.5% | 269.73 | 1 ML
Pardoprunox (SLV-308) hydrochloride is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC50s of 8, 9.2, and 6.3, respectively. It is for research use only.
- Potent but partial D2 receptor agonist (pEC50= 8.0 and pA2=8.4) with 50% efficacy on forskolin stimulated cAMP accumulation.
- Acts as a partial agonist at human recombinant dopamine D3 receptors in the induction of [(35)S]GTPgammaS binding (intrinsic activity of 67%; pEC50=9.2) and antagonizes dopamine induction of [(35)S]GTPgammaS binding (pA2=9.0).
- Acts as a full 5-HT1A receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT1A receptors, though with low potency (pEC50=6.3).
- Available in solid form and as a solution in DMSO.
- Underwent clinical trials for early stage Parkinson's disease and advanced stage Parkinson's disease.
Apexbio Technology LLC NPS-1034 1221713-92-3 10mg
NPS-1034 (CAS 1221713-92-3) is a potent inhibitor of the receptor tyrosine kinase MET with an IC50 of 4 nmol/L MET activated by hepatocyte growth factor is implicated in morphogenesis and tumor progression across various cancers NPS-1034 suppresses cell viability in MET-overexpressing and phosphorylated MET-positive cell lines such as MKN45 and SNU638 with IC50 values of 112 7 nmol/L and 190 3 nmol/L respectively In vivo oral administration of NPS-1034 reduces tumor growth and angiogenesis in MKN45 xenograft models These characteristics support the utility of NPS-1034 in studying MET-driven oncogenic signaling and its therapeutic targeting
Medchemexpress LLC Pilsicainide hydrochloride | 88069-49-2 | MFCD00903769 | 99.9% | 308.85 g·mol⁻¹ | C17H25ClN2O | 25 MG
Pilsicainide hydrochloride is the hydrochloride salt of pilsicainide, an orally active sodium channel blocker and potent class Ic antiarrhythmic agent. It is supplied as a high-purity solid for preclinical pharmacology, electrophysiology, and biochemical research.
- Orally active sodium channel blocker.
- Potent class Ic antiarrhythmic activity.
- High reported purity (>99.9%).
- Molecular formula C17H25ClN2O; molecular weight 308.85 g·mol⁻¹.
- Suitable for pharmacological and electrophysiological studies.
- Available in research-scale pack sizes.
Medchemexpress LLC (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(3,4-difluorophenyl)propionic acid | 198474-90-7 | 98.02% | C14H17F2NO4 | 1 G
This product is a phenylalanine derivative. As an amino acid derivative, it has been explored for its potential to act as an ergogenic dietary substance, influencing the secretion of anabolic hormones, supplying fuel during exercise, enhancing mental performance, and helping prevent exercise-induced muscle damage.
- Solid with a white to light yellow appearance.
- For research use only.
Apexbio Technology LLC Methenamine 10mM (in 1mL DMSO)
B1972 is a small molecule designed for biomedical research applications It modulates specific cellular signaling pathways thereby influencing target protein function at the molecular level B1972 has been utilized in studies investigating pathway regulation cell proliferation and disease models where pathway dysregulation occurs Its application enables the elucidation of signaling mechanisms and supports the development of targeted therapeutic strategies in preclinical research contexts
![Apexbio Technology LLC HBcAg [Hepatitis B virus] (18-27) 1mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000096656.png-250.jpg)
Apexbio Technology LLC HBcAg [Hepatitis B virus] (18-27) 1mg
HBcAg Hepatitis B virus 18-27 is a viral antigen derived from the hepatitis B virus (HBV) core region HBcAg is produced during active viral replication and serves as a marker for intracellular HBV presence Detection and quantitation of HBcAg enable investigation of viral replication mechanisms and monitoring of HBV infection status Based on these properties HBcAg Hepatitis B virus 18-27 holds research potential in immunological assays vaccine studies antiviral agent evaluation and studies of host-virus interactions and immune modulation
Apexbio Technology LLC Epinastine HCl 108929-04-0 10mM (in 1mL DMSO)
Epinastine hydrochloride (CAS 108929-04-0) is a small molecule antagonist of the histamine H1 receptor and a mast cell stabilizer By inhibiting H1 receptor-mediated signaling and preventing the degranulation of mast cells epinastine suppresses the release of pro-inflammatory mediators such as histamine It is commonly applied in ophthalmic research models to investigate mechanisms underlying allergic conjunctival inflammation and to evaluate antiallergic therapies Epinastine hydrochloride is used to study the modulation of allergic responses at the cellular and molecular levels particularly within ocular tissues
Apexbio Technology LLC Phenazopyridine HCl 136-40-3 10mM (in 1mL DMSO)
Phenazopyridine HCl (CAS 136-40-3) is a small-molecule antagonist with competitive inhibitory activity (IC50 145 M) It exerts local analgesic effects primarily through topical action on the urinary tract mucosa thus alleviating pain symptoms associated with bladder and urethral irritation In experimental research phenazopyridine HCl is utilized in models investigating pain transmission pathways urinary tract epithelial responses and inflammatory modulation Based on these pharmacological properties phenazopyridine HCl holds research potential in the study of urinary tract inflammation epithelial permeability nerve differentiation and in assays evaluating analgesic activity in urological and neurobiological research
Medchemexpress LLC 2-Methoxyestrone-d4 | 949885-90-9 | 98.0% | 304.42 | 1 MG
2-Methoxyestrone-d4 is the deuterium labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81. It can be used as a tracer or an internal standard for quantitative analysis.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.