Choose the brand aligned with your industry so we can best serve your needs.
For researchers, scientists, and technical professionals: Your one-stop shop for the complete range of laboratory, production, and safety products and services.
Aromatic organic compounds that consist of a phenyl functional group (−C6H5) bonded to a hydroxyl functional group (−OH). Includes compounds with more substitutions and derivatives.
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
TC-H 106 (CAS 937039-45-7) is a selective inhibitor of class I histone deacetylases (HDACs) targeting HDAC1 HDAC2 HDAC3 and HDAC8 with reported IC50 values of 150 nM 760 nM 370 nM and 5000 nM respectively By inhibiting HDAC activity TC-H 106 interferes with the removal of acetyl groups from histone lysine residues thereby modulating chromatin structure and gene expression In cellular assays TC-H 106 increases histone H3 acetylation in lymphoblastoid cells derived from Friedreich s ataxia (FRDA) patients and enhances frataxin mRNA levels in FRDA mouse models These findings highlight its application in studying epigenetic mechanisms and therapeutic approaches related to HDAC inhibition particularly in neurodegenerative disease models
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
TC-H 106 (CAS 937039-45-7) is a selective inhibitor of class I histone deacetylases (HDACs) targeting HDAC1 HDAC2 HDAC3 and HDAC8 with reported IC50 values of 150 nM 760 nM 370 nM and 5000 nM respectively By inhibiting HDAC activity TC-H 106 interferes with the removal of acetyl groups from histone lysine residues thereby modulating chromatin structure and gene expression In cellular assays TC-H 106 increases histone H3 acetylation in lymphoblastoid cells derived from Friedreich s ataxia (FRDA) patients and enhances frataxin mRNA levels in FRDA mouse models These findings highlight its application in studying epigenetic mechanisms and therapeutic approaches related to HDAC inhibition particularly in neurodegenerative disease models
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More