Phenols
Medchemexpress LLC Soyasaponin Aa | 117230-33-8 | 1 MG
Soyasaponin Aa is a soyasaponin that exerts an anti-obesity effect in 3T3-L1 adipocytes through downregulation of peroxisome proliferator-activated receptor γ (PPARγ).
- Molecular formula: C64H100O31
- Molecular weight: 1365.46
- Target: PPAR
- Pathway: Cell Cycle/DNA Damage, Metabolic Enzyme/Protease, Vitamin D Related/Nuclear Receptor
- In vitro solubility: DMSO 100 mg/mL (73.24 mM)
Medchemexpress LLC Ifebemtinib (hydrochloride) | 1227948-82-4 | 99.2% | 625.01 | 10 MM/1 ML
Ifebemtinib is an orally bioavailable inhibitor of the non-receptor, cytoplasmic tyrosine kinase protein tyrosine kinase 2 (FAK: PTK2) with potential antineoplastic activity. It targets and inhibits PTK2 in an adenosine triphosphate (ATP)-competitive manner, preventing PTK2-mediated downstream signaling and inhibiting migration, proliferation, invasion, and survival in PTK2-overexpressing tumor cells.
- Orally bioavailable inhibitor of FAK1/PTK2
- Targets and inhibits PTK2 in an ATP-competitive manner
- Prevents PTK2-mediated downstream signaling
- Inhibits migration, proliferation, invasion, and survival in PTK2-overexpressing tumor cells
- Stable under recommended storage conditions
Medchemexpress LLC ELA-21 (human) | 2245073-05-4 | 99.97% | 2587.11 | 1 MG
ELA-21 (human) is an apelin receptor agonist that completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. It acts as an agonist in both G-protein-dependent and -independent pathways.
- Apelin receptor agonist with a pKi of 8.52
- Inhibits Forskolin-induced cAMP production
- Stimulates β-arrestin recruitment
- Agonist in G-protein-dependent and -independent pathways
- White to off-white solid appearance
- Soluble in H₂O at 50 mg/mL
Medchemexpress LLC AFM-30a hydrochloride | 99.8% | 502.97 | 1 ML
AFM-30a hydrochloride is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. It inhibits H3 citrullination and is intended for research into certain cancers and various autoimmune diseases, including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis.
- Potent protein arginine deiminase 2 (PAD2) inhibitor.
- Excellent PAD2-selectivity.
- Inhibits H3 citrullination.
- Can be used for research of certain cancers and autoimmune diseases.
- Exhibited low cytotoxicity for cells in a cell viability assay.
- Suppresses NLRP3 signaling and decreases airway remodeling.
Medchemexpress LLC PF-06446846 hydrochloride | 1632250-50-0 | 99.4% | 470.35 | 25 MG
PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). It inhibits PCSK9 by inducing the ribosome to stall around codon 34. This product is intended for research use only and is not sold to patients.
- Orally active and highly selective inhibitor of PCSK9 translation.
- Inhibits PCSK9 by inducing ribosome stalling.
- Lowers plasma PCSK9 and total cholesterol levels in a dose-dependent manner in animal models.
Medchemexpress LLC 1-O-trans-p-Coumaroylglycerol | 106055-11-2 | 95.51% | 238.24 | 5 MG
1-O-trans-p-Coumaroylglycerol is a compound found in certain plants with neuroprotective activity. It has shown potential in protecting against neurodegenerative diseases and is also believed to act as a natural antioxidant. Its applications may include improving cognitive function and supporting neurological health.
- Neuroprotective activity
- Potential in protecting against neurodegenerative diseases
- Acts as a natural antioxidant
- May enhance cognitive function
- May support neurological health
Medchemexpress LLC FHD-609 | 2676211-64-4 | C47H56N8O6 | 100 MG
FHD-609 is a PROTAC degrader and inhibitor of Bromodomain-containing protein 9 (BRD9). It targets ncBAF and is used for research on various cancers with mutations in a BAF complex subunit. This compound, when combined with Telomelysin or INO5401, may be useful in adrenocortical carcinoma (ACC) treatment.
- Purity: 98.95%
- Appearance: Solid, white to off-white
- Target: BRD9, epigenetic reader domain, PROTACs
- Demonstrates maintained BRD9 degradation levels and anti-tumor activities in SYO-1 xenograft mouse models
- In vitro solubility: Soluble in DMSO at 100 mg/mL (120.63 mM), requires ultrasonication
- In vivo solubility: Forms clear solutions in 10% DMSO with 90% (20% SBE-β-CD in saline) or 90% corn oil at ≥ 2.5 mg/mL (3.02 mM)