BN82002 hydrochloride is a potent, selective, and irreversible inhibitor of the CDC25 phosphatase family. It inhibits CDC25A, CDC25B2, CDC25B3, CDC25C, and 25C-cat with IC50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 μM, respectively. It demonstrates approximately 20-fold greater selectivity over CD45 tyrosine phosphatase. It is intended for research use only and is not sold to patients.
- Potent, selective, and irreversible inhibitor of CDC25 phosphatase family.
- Inhibits CDC25A, CDC25B2, CDC25B3, CDC25C, and 25C-cat at micromolar concentrations.
- Displays ~20-fold greater selectivity over CD45 tyrosine phosphatase.
- Shown to inhibit cell proliferation in several human tumor cell lines in vitro in a concentration-dependent manner.
- Causes cell cycle arrest at various stages.