Phenols
Apexbio Technology LLC STO-609 acetate 1173022-21-3 10mg
STO-609 acetate (CAS 1173022-21-3) is a selective inhibitor of Ca2 /calmodulin-dependent protein kinase kinase (CaM-KK) demonstrating Ki values of 80 ng/ml for CaM-KK and 15 ng/ml for CaM-KK This compound exhibits marked specificity for CaM-KK isoforms with minimal activity against downstream CaM kinases such as CaM-KI and CaM-KIV and an IC50 of approximately 10 g/ml for CaM-KII In cell-based studies STO-609 suppresses Ca2 -induced activation of CaM-KIV and reduces endogenous CaM-KK activity In vivo STO-609 administration enhances osteoblast formation and inhibits osteoclast differentiation in mouse models highlighting its utility in studies of calcium signaling and bone metabolism
Apexbio Technology LLC L-798,106 244101-02-8 5mg
L-798 106 (CAS 244101-02-8) is a highly selective antagonist of the prostaglandin E2 (EP3) receptor Binding studies demonstrate a strong affinity for the EP3 receptor with a Ki of 0 3 nM while showing substantially reduced affinity for EP1 ( 5000 nM) EP2 ( 5000 nM) and EP4 (916 nM) receptors By selectively inhibiting EP3 receptor-mediated signaling L-798 106 is utilized to investigate the physiological and pathological roles of EP3 in various disease models and serves as a molecular tool in the preclinical evaluation of EP3-targeted therapeutic strategies
Medchemexpress LLC Acetaminophen | 103-90-2 | 99.97% | C8H9NO2 | 50 MG
Acetaminophen (Standard) is the analytical standard of Acetaminophen, intended for research and analytical applications. Also known as Paracetamol, it is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM, and a widely used antipyretic and analgesic agent. It also acts as a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
- Analytical standard grade
- Reference standard supplied assay
- Used in qualitative research experiments
- Used in quantitative research experiments
- Used in methodological research experiments
- Suitable for HPLC
- Suitable for GC
- Suitable for MS
Medchemexpress LLC Bis(2,4,6-trichlorophenyl) oxalate | 1165-91-9 | MFCD00043061 | 98.0% | 448.90 g·mol⁻1 | C14H4Cl6O4 | 5 G
Bis(2,4,6-trichlorophenyl) oxalate is an aryl oxalate reagent supplied for research use. It is provided as a solid at high purity for laboratory applications and is commonly used in chemiluminescent assays and organic synthesis.
- High purity (98.0%).
- Available in small laboratory pack sizes including 5 g.
- Used as a chemiluminescent reagent and in dye synthesis.
- Solid form, typically packaged in a glass bottle.
- CAS number 1165-91-9; molecular formula C14H4Cl6O4; molecular weight 448.90 g·mol⁻1.
Apexbio Technology LLC Ansamitocin P-3 66547-09-9 10mM (in 1mL DMSO)
Ansamitocin P-3 (CAS 66547-09-9) is a small-molecule inhibitor targeting tubulin It is designed to disrupt microtubule assembly by potently inhibiting tubulin polymerization thereby affecting cellular processes reliant on microtubule dynamics Ansamitocin P-3 exerts its biological activity primarily through inhibition of tubulin polymerization In cell-based studies Ansamitocin P-3 demonstrates cytotoxicity with IC50 values of approximately 4 10 g/ml in human lung carcinoma A-549 and colon carcinoma HT-29 cells and 2 10 g/ml in breast carcinoma MCF-7 cells Additionally it inhibits ciliary regeneration in Tetrahymena cells at concentrations around 1 M Based on these pharmacological properties Ansamitocin P-3 holds research potential in oncology particularly in studies of microtubule dynamics anticancer drug mechanisms and ciliogenesis
Apexbio Technology LLC Olsalazine Sodium 6054-98-4 10mM (in 1mL H2O)
Olsalazine Sodium (CAS 6054-98-4) is a small-molecule anti-inflammatory agent It is designed to modulate inflammatory pathways thereby reducing the production of local inflammatory mediators Olsalazine Sodium exerts its biological activity primarily through inhibition of prostaglandin and leukotriene synthesis pathways after biotransformation by gut microbiota into 5-aminosalicylic acid (5-ASA) In experimental settings researchers employ olsalazine sodium to investigate disease mechanisms underlying colonic inflammation and to evaluate therapeutic responses in models of intestinal inflammation Currently precise IC50 values for olsalazine sodium have not been reported in the literature Based on these pharmacological properties olsalazine sodium holds research potential in inflammatory bowel disease (IBD) especially ulcerative colitis