ONO-AE3-208, also known as AE 3-208, is a selective and orally active EP4 receptor antagonist with a Ki of 1.3 nM. It demonstrates less potent effects on EP3, FP, and TP receptors. This compound is capable of suppressing cell invasion, migration, and metastasis of prostate cancer, showing dose-dependent inhibition of cell invasion and migration in vitro without affecting proliferation. In vivo studies indicate that ONO-AE3-208 suppresses the bone metastasis of PC3 cells in mice.
- Suppresses cell invasion, migration, and metastasis of prostate cancer
- Inhibits cell invasion and migration in a dose-dependent manner in vitro
- Does not affect cell proliferation in vitro
- Abolishes CTGF in the presence of the EET synthesis inhibitor MS-PPOH
- Blocks arachidonic acid (AA)-induced dilation of the attached Af-Art
- Suppresses bone metastasis of PC3 cells in mice