Phenols
Medchemexpress LLC 2',3'-Dideoxyadenosine 5'-triphosphate (trisodium) | 72029-21-1 | 99.9% | 54 MG
ddATP (2',3'-Dideoxyadenosine 5'-triphosphate) trisodium is an active metabolite of 2',3'-dideoxyinosine. It functions as a chain-elongating inhibitor of DNA polymerase and is useful for various applications.
- Inhibitor of DNA polymerase
- Used for Sanger method for DNA sequencing
- Aids in research of virus infection
- Inhibits adenovirus DNA synthesis
- Reduces γH2A.X foci in DSB oocytes
- Inhibits HIV replication by inhibiting reverse transcriptase
Medchemexpress LLC N-(p-Coumaroyl) Serotonin | 68573-24-0 | 99.0% | 1 ML
N-(p-Coumaroyl) Serotonin is a selective inhibitor of PDGFRβ, ERK1/2, and caspase-8, possessing antioxidant, anti-atherosclerotic, and anti-inflammatory properties. This compound inhibits glioblastoma cells and has the potential to improve atherosclerosis and aortic wall enlargement. It is for research use only.
- Selective inhibitor of PDGFRβ, ERK1/2, and caspase-8
- Possesses antioxidant, anti-atherosclerotic, and anti-inflammatory properties
- Inhibits glioblastoma cells (U251MG, T98G) with IC50 values ranging from 48-81 μM
- Works by inhibiting PDGF signaling, blocking Ca2+ influx, and inducing apoptosis
- Potential to improve atherosclerosis and aortic wall enlargement
- Useful in glioblastoma research
TARGETMOL CHEMICALS INC FOSAPREPITANT DIMEGLUMIN 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant the water-soluble N-phosphorylated prodrug of aprepitant with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant this agent binds selectively to the human substance P/neurokinin 1 (NK1) receptors in the central nervous system (CNS). This inhibits receptor binding of the endogenous substance P and prevents substance P-induced emesis. purity: 98%
eMolecules 5-Hydroxyisophthalonitrile | 79370-78-8 | MFCD11865326 | 1g
Ambeed | 5-Hydroxyisophthalonitrile | 1g | 525004633 | A112341 | | 79370-78-8 | MFCD11865326 | 144.133 | C8H4N2O
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Medchemexpress LLC Nvp-bsk805 dihydrochloride | 1942919-79-0 | 99.4% | 563.47 | 1 ML
NVP-BSK805 dihydrochloride is a potent, ATP-competitive JAK2 inhibitor. It targets JAK2 JH1, wild-type JAK2, and FL JAK2 V617F activity, effectively suppressing the growth of JAK2V617F-bearing acute myeloid leukemia cell lines and blocking STAT5 phosphorylation. It also enhances the efficacy of vincristine treatment in drug-resistant cancer cells.
- ATP-competitive inhibitor.
- Highly potent and selective JAK2 inhibitor.
- Inhibits full-length wild-type JAK2 and FL JAK2 V617F activity.
- Suppresses the growth of JAK2V617F-bearing acute myeloid leukemia cell lines.
- Blocks STAT5 phosphorylation.
- Shows bias for JAK2 over JAK1 and JAK3 inhibition.
- Improves P-gp inhibitory activity.
- Increases sensitization of drug-resistant cancer cells to vincristine treatment.
Apexbio Technology LLC GM 6001 142880-36-2 5mg
GM 6001 (Ilomastat Galardin CAS 142880-36-2) is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) including MMP-1 -2 -3 -8 and -9 with reported Ki values of 0 4 nM 0 5 nM 27 nM 0 1 nM and 0 2 nM respectively MMPs participate in extracellular matrix remodeling and mediate signaling events induced by GPCR agonists through EGFR transactivation GM 6001 suppresses EGFR phosphorylation ERK activation and subsequent DNA synthesis induced by stimuli such as bombesin and lysophosphatidic acid (LPA) Additionally this compound has potential applications in cartilage research facilitating meniscal repair under inflammatory conditions by dampening IL-1-mediated MMP activity
Medchemexpress LLC 5-Bromo-3-methylpyridin-2-ol | 89488-30-2 | 99.7% | C6H6BrNO | 25 G
5-Bromo-3-methylpyridin-2-ol, also known as 5-Bromo-3-methylpyridin-2(1H)-one, is a high-purity (99.71%) biochemical reagent. This white to off-white solid has a molecular weight of 188.02 and chemical formula C6H6BrNO (CAS No. 89488-30-2). It is utilized as a biological material or organic compound for life science research. It is soluble in DMSO at 100 mg/mL, requiring ultrasonication, and newly opened DMSO is recommended.
- Purity: 99.71%
- Appearance: White to off-white solid
- CAS No.: 89488-30-2
- Molecular weight: 188.02
- Formula: C6H6BrNO
- Uses: Biochemical reagent for life science research
- Solubility: 100 mg/mL in DMSO (requires ultrasonication)
- Storage: Powder: -20°C for 3 years, 4°C for 2 years; In solvent: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC AFM32a hydrochloride | 2988594-85-8 | 99.4% | 517.00 | 25 MG
This benzimidazole-based derivative is a potent and selective protein arginine deiminase 2 inhibitor. It exhibits superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold).
- Potent and selective protein arginine deiminase 2 inhibitor.
- Superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold).
Medchemexpress LLC Venlafaxine (hydrochloride) | 99300-78-4 | MFCD03658865 | >99.9% | 100 MG
Venlafaxine hydrochloride is an analytical standard used in research and analytical applications. It functions as an orally active, potent serotonin (5-HT) and norepinephrine (NE) reuptake dual inhibitor, recognized as an antidepressant. This compound is suitable for qualitative, quantitative, and methodological research experiments, including HPLC, GC, and MS.
- Analytical standard for research and analysis
- Potent serotonin and norepinephrine reuptake inhibitor
- Antidepressant properties
- Suitable for HPLC, GC, and MS applications
- Molecular formula: C₁₇H₂₈ClNO₂
- Molecular weight: 313.86
- Appears as a white to off-white solid
- Recommended storage: 4°C, sealed, away from light and moisture
Medchemexpress LLC N-(p-Coumaroyl) Serotonin | 68573-24-0 | 99.0% | 10 MG
N-(p-Coumaroyl) Serotonin is a selective inhibitor of PDGFRβ, ERK1/2, and caspase-8, exhibiting antioxidant, anti-atherosclerotic, and anti-inflammatory properties. It inhibits glioblastoma cells and can improve atherosclerosis and aortic wall enlargement.
- Selective inhibitor of PDGFRβ, ERK1/2, and caspase-8
- Exhibits antioxidant, anti-atherosclerotic, and anti-inflammatory properties
- Inhibits glioblastoma cells
- Blocks calcium influx
- Induces apoptosis by activating caspase-8
- Can improve atherosclerosis and aortic wall enlargement
- Used in glioblastoma research
Medchemexpress LLC Pilocarpine hydrochloride | 54-71-7 | 99.98% | 5 G
Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist. It is intended for research use only.
- Potent M3-type muscarinic acetylcholine receptor agonist
- Unstable in solutions, freshly prepared is recommended
- Suitable for laboratory centrifugation and storage
Medchemexpress LLC Sotalol hydrochloride | 959-24-0 | MFCD00870503 | ≥99.0% | 200 MG
Sotalol hydrochloride is an orally active, non-selective β-adrenergic receptor blocker and a potent antiarrhythmic agent. It is suitable for research on pediatric arrhythmias and also functions as an antiepileptic agent. This compound works by blocking β-receptors and potassium KCNH2 channels.
- Orally active, non-selective β-adrenergic receptor blocker
- Potent antiarrhythmic agent
- Can be used for research of pediatric arrhythmias
- Blocks β-receptors
- Blocks potassium KCNH2 channels
- Functions as an antiepileptic agent
- Target for adrenergic receptor and potassium channel research
- Relevant for cardiovascular disease and neurological disease research
- Stable under recommended storage conditions
- Available as a solid
Medchemexpress LLC Cyclobenzaprine hydrochloride | 6202-23-9 | 100 MG
Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT2 receptor antagonist that acts centrally to provide skeletal muscle relaxation, alleviate muscle spasms, and reduce pain. It also possesses antiparasitic activity. Cyclobenzaprine hydrochloride shows promise for research in acute, painful skeletal muscle disorders and infectious diseases.
- Acts centrally to provide skeletal muscle relaxation
- Alleviates muscle spasms and reduces pain
- Possesses antiparasitic activity
- Shows promise for research in acute, painful skeletal muscle disorders
- Shows promise for research in infectious diseases