Choose the brand aligned with your industry so we can best serve your needs.
For researchers, scientists, and technical professionals: Your one-stop shop for the complete range of laboratory, production, and safety products and services.
Aromatic organic compounds that consist of a phenyl functional group (−C6H5) bonded to a hydroxyl functional group (−OH). Includes compounds with more substitutions and derivatives.
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Bazedoxifene HCl (198480-56-7) is a non-steroidal selective estrogen receptor modulator (SERM) targeting estrogen receptor subtypes ER and ER It is designed to bind ERs thereby modulating estrogen receptor-mediated signaling pathways Bazedoxifene HCl exerts its biological activity primarily by antagonizing ER -mediated transcriptional activity thereby inhibiting estradiol-induced cell proliferation In cell-based studies Bazedoxifene HCl demonstrates inhibition of cell proliferation in human breast cancer (MCF-7) ovarian (CHO) hepatic (HepG2) and neuronal (GT1-7) cell lines The compound exhibits binding affinities (Ki) of 26 nM for ER and 99 nM for ER Based on these pharmacological properties Bazedoxifene HCl holds research potential in osteoporosis and estrogen receptor-mediated diseases including breast ovarian and uterine cancers
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More