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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
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m-PEG8-CH2COOH is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. These compounds operate by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
PEG-based linker
Used in the synthesis of PROTACs
Selectively degrades target proteins
Molecular weight: 442.50
Formula: C19H38O11
Appearance: Liquid
Color: Colorless to light yellow
Soluble in DMSO (200 mg/mL)
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Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs are designed with two different ligands connected by this linker: one targeting an E3 ubiquitin ligase and the other for a specific protein. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Functions as a PEG-based PROTAC linker
Essential for the synthesis of PROTACs
Enables selective degradation of target proteins
Utilizes the intracellular ubiquitin-proteasome system
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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ζ-Stat trisodium (1-naphthol-3,6,8-trisulfonic acid trisodium salt) is the trisodium salt research reagent that functions as a selective atypical protein kinase C-ζ (PKC-ζ) inhibitor with reported in vitro antitumor activity (IC50 ≈ 5 μM). It reduces proliferation and induces apoptosis in certain melanoma cell lines and is supplied as a solid for biochemical and cell-based assays.
Selective atypical PKC-ζ inhibitor (IC50 ≈ 5 μM).
Demonstrated antiproliferative and pro-apoptotic activity in melanoma cell lines.
Solid, light yellow appearance; purity 97.0%.
Water soluble: 12.5 mg/mL in H2O with ultrasonic/warming (heat to 60°C).
Store sealed, away from moisture; recommend 4°C; in solution keep at -80°C (6 months) or -20°C (1 month).
Available in small research pack sizes including 10 mg.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More