TH-6 is a potent HDAC inhibitor with IC50s of 0.115, 0.135, 0.242, 0.138, and 2.120 μM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, respectively. It demonstrates anti-tumor activity and inhibits cell migration and invasion, inducing apoptosis and cell cycle arrest at the G2/M phase.
- Inhibits cell migration and invasion
- Induces apoptosis
- Causes cell cycle arrest at the G2/M phase
- Demonstrates anti-tumor activity
- Potent HDAC inhibitor