Azoles
Apexbio Technology LLC YL-109 36341-25-0 10mM (in 1mL DMSO)
YL-109 (CAS 36341-25-0) is a small molecule with demonstrated antitumor properties primarily acting through modulation of the aryl hydrocarbon receptor (AhR) signaling pathway This compound enhances expression of the molecular chaperone-associated ubiquitin ligase CHIP (C-terminus of Hsp70-interacting protein) leading to downstream regulation of processes implicated in cell proliferation and invasion In breast cancer models YL-109 induces CHIP expression resulting in suppressed proliferation and invasive capabilities of cancer cells YL-109 is thus a valuable tool for investigating AhR-mediated anticancer mechanisms and exploring therapeutic strategies in breast cancer research
Apexbio Technology LLC ODQ 41443-28-1 10mg
ODQ (CAS 41443-28-1) is a selective inhibitor of soluble guanylate cyclase (sGC) interfering with nitric oxide (NO)-dependent intracellular signaling by blocking sGC-mediated catalysis of cyclic guanosine monophosphate (cGMP) synthesis This inhibition results in reduced cGMP production and subsequent modulation of protein kinase G-regulated cellular processes Studies have demonstrated that ODQ enhances cisplatin-induced apoptosis in human mesothelioma cells in vitro supporting its use in investigating tumor cell apoptosis mechanisms and evaluating synergistic effects in anticancer drug research
Medchemexpress LLC Chitin, from crab carapace (powder), biomedical research grade | 1398-61-4 | 100 G
Chitin, from crab carapace is a long-chain polymer of N-acetylglucosamine with β-(1-4) linkages. It is found in the exoskeleton of crabs. This product inhibits the activation of NF-κB p65, alters the translocation of NF-κB p65 to the nucleus, and interacts with the cell wall of Candida species. It exerts antifungal and anti-inflammatory effects and can be used in the research of gastric ulcer and candidiasis.
- Shows antifungal activity against 20 clinical isolates of Candida spp.
- Significantly reduces gastric ulcer index and inhibits NF-κB p65 expression in the Wistar rat model.
- Results in decreased necrotic cells and fat degeneration, and increased normal cells in gastric mucosa.
eMolecules Synthonix / 46-diiodo-2-methylpyrimidine / 500mg / 784553408 / AC78565 / / 66298-49-5 / MFCD11040177 / 345.910 / C5H4I2N2
Synthonix / 46-diiodo-2-methylpyrimidine / 500mg / 784553408 / AC78565 / / 66298-49-5 / MFCD11040177 / 345.910 / C5H4I2N2
Medchemexpress LLC 4-(4-cyclopropyl-1H-imidazol-1-yl)-N-(3-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)phenyl)picolinamide | 1262041-49-5 | Not listed | 99.6% | 411.46 | C23H21N7O | 25 MG
GS-444217 is a selective, orally available ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1). It exhibits potent in vitro inhibition (IC50 2.87 nM) and has reported in vivo activity in rodent kidney (in vivo EC50 ≈ 1.6 μM; activity observed at 30 mg/kg). The compound is supplied as a research-grade powder.
- Selective ATP-competitive ASK1 inhibitor.
- Potent in vitro activity: IC50 2.87 nM.
- Demonstrated in vivo activity in rodent kidney (in vivo EC50 ≈ 1.6 μM).
- Supplied as a powder for research use.
- Molecular formula C23H21N7O; molecular weight 411.46.
- CAS number 1262041-49-5.
eMolecules Mizolastine | 108612-45-9 | 1G | Purity: 98%
Combi-Blocks | Mizolastine | 1G | 108612-45-9 | MFCD00864625
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Medchemexpress LLC TH-Z93 | 2260887-09-8 | C12H22N2O7P2 | 5 MG
TH-Z93 is a lipophilic bisphosphonate that acts as an FPPS inhibitor with an IC50 of 90 nM. It exhibits strong prophylactic effects in a pathogenic influenza model, inhibiting tumor growth and prolonging survival in a B16-OVA cells (s.c.) xenograft mice model. It is for research use only.
- FPPS inhibitor with an IC50 of 90 nM
- Exhibits strong prophylactic effects in pathogenic influenza model
- Inhibits tumor growth and prolongs survival in xenograft mice model
Medchemexpress LLC A synthetic superoxide dismutase and catalase mimetic | 81065-76-1 | 98.3% | 416.74 | C18H18ClMnN2O4 | 50 MG
EUK-134 is a synthetic small-molecule antioxidant with combined superoxide dismutase and catalase mimetic activity. It is supplied as a high-purity solid for research use in cell and animal models to investigate oxidative stress, mitochondrial protection, and related signaling pathways.
- Catalytically scavenges reactive oxygen species (ROS).
- Exhibits superoxide dismutase and catalase mimetic activity.
- Used in vitro and in vivo to study oxidative stress and mitochondrial function.
- High purity suitable for biochemical and cellular assays.
- Supplied as 50 mg solid for laboratory use.
Medchemexpress LLC 1-(4-Chlorophenyl)piperazine | 38212-33-8 | 196.68 | 100 G
1-(4-Chlorophenyl)piperazine is a chemical intermediate that can be used for the synthesis of D2R ligand. It is for research use only.
- Chemical intermediate
- Can be used for synthesis of D2R ligand
- For research use only
- Solid appearance
- White to light yellow color
Medchemexpress LLC (2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone | 141645-16-1 | 99.6% | C19H17NO5 | 10 G
(2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone is a drug intermediate for the synthesis of various active compounds.
- Used for synthesis of various active compounds.
- For research use only.
Medchemexpress LLC 2,5-Dibromothiazole | 4175-78-4 | 99.8% | C3HBr2NS | 10 G
2,5-Dibromothiazole is a heterocyclic compound and a key intermediate in organic synthesis.
- Heterocyclic compound
- Key intermediate in organic synthesis
- Appears as an off-white to yellow solid
- Provided with high purity
- Specific storage recommendations for powder and in solvent solutions