RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM in cell-free assays RAF265 (CHIR-265) induces cell cycle arrest and apoptosis Phase 2