Imidazoleacetic acid is a blood-brain barrier-permeable full agonist of the GABAA receptor. It is formed via histamine oxidation in the mouse brain and exerts multiple neurochemical and behavioral effects.
- Acts as a full agonist of the GABAA receptor
- Formed via histamine oxidation in the mouse brain
- Exerts multiple neurochemical effects
- Induces analgesia, sedation, and hypnosis
- Reduces blood pressure and body temperature
- Decreases isolation-induced aggression and motor activity