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Organic compounds that consist of a benzene ring substituted with amino and carboxyl groups. Includes compounds that are derived from aminobenzoic acids.
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Concanamycin A is a macrolide antibiotic and a vacuolar type H+-ATPase (V-ATPase) inhibitor. It also inhibits lysosomal acidification and can be used in T cell-mediated inflammation research.
Macrolide antibiotic
Vacuolar type H+-ATPase (V-ATPase) inhibitor
Inhibitor of lysosomal acidification
Can be used for T cell-mediated inflammation research
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
6-Methylnicotinic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It also serves as an intermediate in the synthesis of drugs like etoricoxib, which is used for treating arthritis and osteoarthritis. This product appears as a white to off-white solid.
Used as a biochemical reagent in life science research
Functions as an organic intermediate for drug synthesis
Has an appearance of a white to off-white solid
High purity of 99.75%
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Concanamycin A (CAS 80890-47-7) is a selective inhibitor of vacuolar-type ATPase (V-ATPase) displaying an IC50 of approximately 10 nM Its mechanism involves direct binding to the V(o) subunit c of V-ATPase thereby inhibiting proton transport across cell membranes Through blockade of V-ATPase activity concanamycin A inhibits endosomal acidification disrupts intracellular trafficking processes and interferes with extracellular matrix pH maintenance resulting in apoptosis induction in tumor cells including oral squamous cell carcinoma and prostate cancer lines and reduced tumor cell invasiveness It is employed extensively in cancer biology research to investigate V-ATPase-mediated pathways and explore therapeutic resistance mechanisms
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Concanamycin A (CAS 80890-47-7) is a selective inhibitor of vacuolar-type ATPase (V-ATPase) displaying an IC50 of approximately 10 nM Its mechanism involves direct binding to the V(o) subunit c of V-ATPase thereby inhibiting proton transport across cell membranes Through blockade of V-ATPase activity concanamycin A inhibits endosomal acidification disrupts intracellular trafficking processes and interferes with extracellular matrix pH maintenance resulting in apoptosis induction in tumor cells including oral squamous cell carcinoma and prostate cancer lines and reduced tumor cell invasiveness It is employed extensively in cancer biology research to investigate V-ATPase-mediated pathways and explore therapeutic resistance mechanisms
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More