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Apexbio Technology LLC Concanamycin A(Synonyms: Folimycin, Concanamycin-A, ConcanamycinA, Concanamycin A (Folimycin), Folimycins), 1mg, CAS: 80890-47-7.
Supplier: Apexbio Technology LLC A86331
Concanamycin A (CAS 80890-47-7) is a selective inhibitor of vacuolar-type ATPase (V-ATPase) displaying an IC50 of approximately 10 nM Its mechanism involves direct binding to the V(o) subunit c of V-ATPase thereby inhibiting proton transport across cell membranes Through blockade of V-ATPase activity concanamycin A inhibits endosomal acidification disrupts intracellular trafficking processes and interferes with extracellular matrix pH maintenance resulting in apoptosis induction in tumor cells including oral squamous cell carcinoma and prostate cancer lines and reduced tumor cell invasiveness It is employed extensively in cancer biology research to investigate V-ATPase-mediated pathways and explore therapeutic resistance mechanisms
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