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Apexbio Technology LLC Concanamycin A(Synonyms: Folimycin, Concanamycin-A, ConcanamycinA, Concanamycin A (Folimycin), Folimycins), 1mg, CAS: 80890-47-7.
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Catalog No. 5000060594
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Concanamycin A (CAS 80890-47-7) is a selective inhibitor of vacuolar-type ATPase (V-ATPase) displaying an IC50 of approximately 10 nM Its mechanism involves direct binding to the V(o) subunit c of V-ATPase thereby inhibiting proton transport across cell membranes Through blockade of V-ATPase activity concanamycin A inhibits endosomal acidification disrupts intracellular trafficking processes and interferes with extracellular matrix pH maintenance resulting in apoptosis induction in tumor cells including oral squamous cell carcinoma and prostate cancer lines and reduced tumor cell invasiveness It is employed extensively in cancer biology research to investigate V-ATPase-mediated pathways and explore therapeutic resistance mechanisms

Catalog No. 50-000-60594 Supplier Apexbio Technology LLC Supplier No. A86331
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Concanamycin A (CAS 80890-47-7) is a selective inhibitor of vacuolar-type ATPase (V-ATPase) displaying an IC50 of approximately 10 nM Its mechanism involves direct binding to the V(o) subunit c of V-ATPase thereby inhibiting proton transport across cell membranes Through blockade of V-ATPase activity concanamycin A inhibits endosomal acidification disrupts intracellular trafficking processes and interferes with extracellular matrix pH maintenance resulting in apoptosis induction in tumor cells including oral squamous cell carcinoma and prostate cancer lines and reduced tumor cell invasiveness It is employed extensively in cancer biology research to investigate V-ATPase-mediated pathways and explore therapeutic resistance mechanisms

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