Licoisoflavone A is an orally active isoflavone that inhibits proliferation, induces apoptosis, and causes G1/S phase arrest in colorectal cancer (CRC) cells by inhibiting the CDK2-Cyclin E1 axis. It demonstrates a dose-dependent inhibitory effect on SARS-CoV-2 infection and significant anti-tumor efficacy in mice, making it useful for research into colorectal cancer and SARS-CoV-2.
- Orally active isoflavone
- Inhibits proliferation, induces apoptosis, and causes G1/S phase arrest in colorectal cancer cells
- Inhibits the CDK2-Cyclin E1 axis
- Inhibits lipid peroxidation (IC50 of 7.2 μM)
- Shows dose-dependent inhibition of SARS-CoV-2 infection
- Exhibits significant anti-tumor efficacy in mice