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Organic compounds that consist of a benzene ring substituted with amino and carboxyl groups. Includes compounds that are derived from aminobenzoic acids.
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A-1155463 is a highly potent and selective chemical probe that acts as a BCL-XL inhibitor, demonstrating an EC50 of 70 nM in Molt-4 cells. It is also a click chemistry reagent due to its Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. For research use only.
Shows picomolar binding affinity to BCL-XL (Ki<0.01 nM).
Demonstrates strong growth inhibition of over half of colorectal cell lines with EC50 values ≤0.5 μM.
Inhibits H146 small cell lung cancer xenograft tumor growth in vivo.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More