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Medchemexpress LLC 2-(8-(Benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-(4-(3-(dimethylamino) | 1235034-55-5 | MFCD29924714 | 99.0% | 669.79 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY1972510MM/1ML

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A-1155463 is a highly potent and selective chemical probe that acts as a BCL-XL inhibitor, demonstrating an EC50 of 70 nM in Molt-4 cells. It is also a click chemistry reagent due to its Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. For research use only.

  • Shows picomolar binding affinity to BCL-XL (Ki＜0.01 nM).
  • Demonstrates strong growth inhibition of over half of colorectal cell lines with EC50 values ≤0.5 μM.
  • Inhibits H146 small cell lung cancer xenograft tumor growth in vivo.

Catalog No. 50-004-01343


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