Benzenesulfonamides
Selleck Chemical LLC Saccharin S4819-25mg
Saccharin (Benzoic sulfimide O-Sulfobenzimide O-Benzoic sulfimide Saccharimide) is an artificial sweetener with effectively no food energy
Cayman Chemical Sildenafil Inhibitors
A PDE5 inhibitor (IC50s = 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively); selective for PDE5 over PDE1 and PDE3 (IC50s = 0.26 and 65 μM, respectively); reverses glucose-induced decreases in ANG1 expression and reduction of capillary-like tube formation by mouse dermal endothelial cells in vitro; increases the number of functional blood vessels and regional blood flow in the sciatic nerve in a db/db mouse model of diabetic peripheral neuropathy; increases ICP/MAP ratio in castrated rats at 20 mg/kg per day; reduces cardiac arrest and resuscitation-induced increases in angiotensin II ACE, ACE2, and various angiotensin receptors and increases survival in a porcine model of ischemia/reperfusion injury
Cayman Chemical Sildenafil Inhibitors
A PDE5 inhibitor (IC50s = 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively); selective for PDE5 over PDE1 and PDE3 (IC50s = 0.26 and 65 μM, respectively); reverses glucose-induced decreases in ANG1 expression and reduction of capillary-like tube formation by mouse dermal endothelial cells in vitro; increases the number of functional blood vessels and regional blood flow in the sciatic nerve in a db/db mouse model of diabetic peripheral neuropathy; increases ICP/MAP ratio in castrated rats at 20 mg/kg per day; reduces cardiac arrest and resuscitation-induced increases in angiotensin II ACE, ACE2, and various angiotensin receptors and increases survival in a porcine model of ischemia/reperfusion injury
Selleck Chemical LLC AK 7
AK 7 is a brain-permeable selective SIRT2 inhibitor with an IC50 of 15 5 M
![eMolecules 171599-83-0 | SILDENAFIL CITRATE | AstaTech | MFCD09026931 | 666.700 | C28H38N6O11S | 95.000 | OC(=O)CC(O)(CC(O)=O)C(O)=O.CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 | 25g | 410712234](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000162673.jpg-250.jpg)
eMolecules 171599-83-0 | SILDENAFIL CITRATE | AstaTech | MFCD09026931 | 666.700 | C28H38N6O11S | 95.000 | OC(=O)CC(O)(CC(O)=O)C(O)=O.CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 | 25g | 410712234
SILDENAFIL CITRATE | AstaTech | 171599-83-0 | MFCD09026931 | 666.700 | C28H38N6O11S | 95.000 | OC(=O)CC(O)(CC(O)=O)C(O)=O.CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 | 25g | 410712234
Medchemexpress LLC Sildenafil (citrate) | 171599-83-0 | C28H38N6O11S | 10 G
Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM. This compound is intended for research use only.
- Potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
- Increases the phosphorylation of ERK1/ERK2.
- Potentiates cell proliferation.
- Enhances the upregulation of ERK1/ERK2 phosphorylation induced by serotonin.
- Significantly increases intracavernosal pressure (ICP) and ICP/blood pressure (BP) ratio in dog models.
- Decreases the number of TL+-cells.
- Reduces the number of microglia/macrophages.
- Decreases flap necrosis by increasing the secretion of growth factors.
Medchemexpress LLC Sildenafil | 139755-83-2 | C22H30N6O4S | 200 MG
Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM. It demonstrates various cellular and in vivo activities, making it suitable for a range of research applications. This product is for research use only.
- Potent PDE5 inhibitor with an IC50 of 5.22 nM
- Inhibits human recombinant PDE5A1
- Potentiates ERK1/ERK2 phosphorylation
- Increases cell proliferation in S phase
- Significantly increases intracavernosal pressure (ICP) in dog models
- Reduces number of TL+-cells and microglia/macrophages in vivo
- Decreases flap necrosis in animal models by enhancing growth factor secretion
Medchemexpress LLC PI3K-IN-1 (XL-147 derivative 1) | 1349796-36-6 | 99.5% | 2 MG
PI3K-IN-1 (XL-147 derivative 1) is a small-molecule inhibitor of phosphoinositide 3-kinase (PI3K) supplied as a research analytical standard. It has reported activity blocking PI3K/Akt signaling at 25 μM and is provided in milligram-scale packages suitable for analytical use.
- Small-molecule PI3K inhibitor for research applications.
- Blocks PI3K/Akt signaling at 25 μM (manufacturer-reported activity).
- Molecular formula C31H29N5O6S; molecular weight 599.66.
- Supplied as an analytical/research standard in milligram-scale packages.
- Suitable for biochemical assays and pathway studies.
Medchemexpress LLC Furosemide | 54-31-9 | 100.0% | 50 MG
Furosemide is an analytical standard intended for research and analytical applications. It is a potent, orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter (NKCC1 and NKCC2) and a GABAA receptor antagonist, showing 100-fold selectivity for α6-containing receptors over α1-containing receptors. Furosemide functions as a loop diuretic and is used for studying congestive heart failure, hypertension, and edema. It is commonly utilized in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Potent and orally active inhibitor of NKCC cotransporter
- GABAA receptor antagonist with high selectivity for α6-containing receptors
- Functions as a loop diuretic
- Used for studying congestive heart failure, hypertension, and edema
- Suitable for qualitative, quantitative, and methodological research experiments
- Applicable in HPLC, GC, and MS analyses
Selleck Chemical LLC Pibrentasvir ABT-530-5mg
Pibrentasvir (ABT-530) is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with EC50 ranging from 1.4 pM to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6.