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Bromobenzenes

Organic compounds considered aryl halides that consist of a phenyl group with a bromine atom substitution in the following structure: C₆H₅Br.

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Medchemexpress LLC 3-[4-[4-(4-bromobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-5-methylpyrazol-1-yl]benzonitrile | 2095486-67-0 | 100.0% | 588.88 g/mol | C29H23BrClN5O2 | 25 MG
SDP

eIF4A3-IN-1 is a selective small-molecule inhibitor of the eukaryotic initiation factor 4A3 (eIF4A3) intended for research use. It inhibits nonsense-mediated RNA decay (NMD), binds the non-ATP site of eIF4A3, and has reported anti-tumor and analgesic activities. Chemical identity: C29H23BrClN5O2, MW 588.88 g/mol, CAS 2095486-67-0; purity 99.96%.

  • selective eIF4A3 inhibition (IC50 0.26 μM; Kd 0.043 μM).
  • high reported purity of 99.96%.
  • soluble in DMSO at 200 mg/mL (requires sonication) for in vitro use.
  • formulation compatible with in vivo vehicle of 10% DMSO/90% corn oil at ≥5 mg/mL.
  • powder and solution storage recommendations for compound stability.
  • available in multiple solid package sizes, including a 25 mg option.

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