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AZ194 is a research small-molecule inhibitor of the CRMP2-Ubc9 interaction and the NaV1.7 sodium channel (IC50 = 1.2 μM). It blocks SUMOylation of CRMP2 and selectively reduces NaV1.7 surface expression, producing antinociceptive effects in preclinical pain models. Supplied as a white to off-white solid for laboratory research use.
Inhibits CRMP2-Ubc9 interaction and NaV1.7 (IC50 = 1.2 μM).
Molecular weight: 567.63 g/mol.
Chemical formula: C34H31F2N3O3.
High purity (>99.8%) suitable for research applications.
Appearance: white to off-white solid.
Soluble in DMSO at approximately 33.33 mg/mL; may require ultrasonic assistance.
Storage recommendations: powder at -20°C or 4°C; aliquot solutions and store at -80°C.
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