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Organic compounds that consist of a phenol ring with a ciclohexane substitution; includes compounds in which the ciclohexane group has additional substitutions.
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Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity.
Inhibits proliferation in HCT116 cells.
Induces apoptosis in HCT116 cells.
Inhibits proliferation in CT26 cells.
Shows selectivity, strongly inhibiting glycolytic tumor cells with mtDNA mutations.
Increases mtROS, especially in glycolytic L929dt and Cybrid cells.
Demonstrates potent antitumor immune effects in the CT26 xenograft model.
Shows synergistic antitumor effects in the MC38 xenograft model, especially with PD-1 blockade.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More