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Medchemexpress LLC Imifoplatin | 1339960-28-9 | 95.0% | 485.23 | 50 MG

Supplier: Medchemexpress LLC HY10914650MG
Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity.
- Inhibits proliferation in HCT116 cells.
- Induces apoptosis in HCT116 cells.
- Inhibits proliferation in CT26 cells.
- Shows selectivity, strongly inhibiting glycolytic tumor cells with mtDNA mutations.
- Increases mtROS, especially in glycolytic L929dt and Cybrid cells.
- Demonstrates potent antitumor immune effects in the CT26 xenograft model.
- Shows synergistic antitumor effects in the MC38 xenograft model, especially with PD-1 blockade.
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