Fluorobenzenes
Medchemexpress LLC Canagliflozin | 842133-18-0 | MFCD18251436 | 5mg
Canagliflozin | Purity: 99.61% | MW: 444.52 | 842133-18-0 | MFCD18251436 | 5mg
Apexbio Technology LLC Canagliflozin(Synonyms: Invokana, TA-7284, JNJ-28431754, Sulisent, Canagliflozin hemihydrate), 100mg, CAS: 842133-18-0.
Canagliflozin (CAS 842133-18-0) is a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2) a transporter responsible for renal glucose reabsorption By inhibiting SGLT2 activity Canagliflozin decreases renal glucose reabsorption resulting in increased urinary glucose excretion In CHO cells expressing human rat or mouse SGLT2 Canagliflozin potently inhibits sodium-dependent glucose uptake with IC50 values of 4 4 3 7 and 2 0 nM respectively Animal studies using db/db mice and Zucker diabetic fatty (ZDF) rats demonstrate dose-dependent reductions in blood glucose as well as decreased respiratory exchange ratio and body weight Canagliflozin is suitable for in vivo research through oral administration
Medchemexpress LLC HY-10451 100mg , Canagliflozin JNJ 24831754ZAE;JNJ 28431754;JNJ 28431754AAA;TA 7284 CAS:842133-18-0 Purity:98%
Medchemexpress, HY-10451 100mg Canagliflozin JNJ 24831754ZAE;JNJ 28431754;JNJ 28431754AAA;TA 7284 CAS:842133-18-0 Formula:C24H25FO5S IC50: 2/3.7/4.4 nM (m/r/hSGLT2, in CHOK cells) Purity:98% Canagliflozin is a selective SGLT2 inhibitor with IC 50 of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.