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Medchemexpress LLC Phd-1-in-1 | 2009343-14-8 | 99.2% | 220.23 | C13H8N4 | 5 MG
PHD-1-IN-1 is a potent, orally active small-molecule inhibitor of hypoxia-inducible factor prolyl-hydroxylase domain-1 (PHD-1) for preclinical research into HIF regulation and hypoxia signaling. It binds the active-site Fe2+ with a unique monodentate interaction and induces an Arg367-out pocket. Supplied as a white to off-white solid with high purity for in vitro and in vivo studies.
- Potent PHD-1 inhibition (IC50 0.034 μM).
- Unique monodentate binding to the active-site iron that alters pocket conformation.
- High purity suitable for research and assay development.
- Soluble in DMSO; manufacturer provides in vivo formulation protocols.
- Stable powder storage conditions for long-term preservation.
