Phenylhydrazines
Medchemexpress LLC Pexidartinib hydrochloride | 2040295-03-0 | 99.8% | 454.28 | 2 G
Pexidartinib hydrochloride is a potent, orally active, selective, and ATP-competitive inhibitor of colony-stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit. It exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases and induces cell apoptosis, showing anti-cancer activity.
- Potent and selective inhibition of CSF1R and c-Kit.
- Induces cell apoptosis.
- Demonstrates anti-cancer activity.
- Shows 10- to 100-fold selectivity over other related kinases.
Medchemexpress LLC Pexidartinib hydrochloride | 2040295-03-0 | 99.8% | 454.28 | 10 G
Pexidartinib hydrochloride is a potent, orally active, selective, and ATP-competitive inhibitor targeting the colony stimulating factor 1 receptor (CSF1R) and c-Kit. It demonstrates significant selectivity over other related kinases and is known to induce cell apoptosis, indicating anti-cancer activity. This compound has been shown to deplete microglia cells in mice and inhibit the proliferation of microglia. It also reduces tissue macrophage levels without affecting glucose homeostasis in mice.
- Potent and selective CSF1R and c-Kit inhibitor
- Orally active and ATP-competitive
- Exhibits 10- to 100-fold selectivity for CSF1R and c-Kit over related kinases
- Induces cell apoptosis
- Shows anti-cancer activity
- Depletes microglia cells in mice
- Inhibits proliferation of microglia
- Reduces tissue macrophage levels
Medchemexpress LLC Bendamustine hydrochloride | 3543-75-7 | 99.9% | C16H22Cl3N3O2 | 500 MG
Bendamustine hydrochloride is a purine analogue and a DNA cross-linking agent. It activates DNA-damage stress response and apoptosis, demonstrating potent alkylating, anticancer, and antimetabolite properties. This compound has been shown to reduce the viability of multiple myeloma cell lines and to induce specific caspase-dependent cell death.
- Functions as a DNA cross-linking agent
- Activates DNA-damage stress response and apoptosis
- Possesses potent alkylating, anticancer, and antimetabolite properties
- Reduces viability of multiple myeloma cell lines
- Induces specific caspase-dependent cell death
- Causes DNA breaks
- Regulates apoptosis and DNA repair pathways in non-Hodgkin's lymphoma cells
- Blocks mitotic checkpoints and causes mitotic catastrophe
Medchemexpress LLC JBSNF-000028 hydrochloride | C11H14ClN3 | 10 MM * 1 ML
JBSNF-000028 hydrochloride is an orally active small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT). It shows anti-obesity and anti-diabetic activities and can be used for the study of metabolic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
- Orally active small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT)
- Reduces endogenous MNA levels in U2OS osteosarcoma cells
- Shows significant anti-obesity and anti-diabetic activities
- Used for the study of metabolic diseases
- Improves glucose and lipid handling in mice with diet-induced obesity (DIO)
- Improves glucose tolerance in NNMT knockout mice with diet-induced obesity