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Ambroxol HCl (CAS 23828-92-4) is a small molecule known for its inhibitory activity on neuronal voltage-gated sodium (Na ) channels It exhibits potent blockade of both tetrodotoxin-resistant (TTX-R) and tetrodotoxin-sensitive (TTX-S) Na currents with half-maximal inhibitory concentrations (IC50) of 35 2 M and 22 5 M for tonic and phasic block of TTX-R currents respectively and 100 M for TTX-S currents These properties position Ambroxol HCl as a valuable tool for investigating sodium channel function and pain signaling pathways and support its evaluation in clinical research settings
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