Deoxyelephantopin is a natural bioactive sesquiterpene lactone derived from Elephantopus scaber. It exhibits promising anticancer effects against a wide range of cancers, functioning by inhibiting NF-κB, MAPK, PI3K/Akt, and β-catenin signaling pathways. It is for research use only.
- Inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling pathways.
- Demonstrates anticancer effects against various cancer cell lines including colorectal, chronic myeloid leukemia, oral, and breast.
- Increases expression of p53, p-JNK, and p-p38 in cancer cells.
- Decreases expression of p-STAT3 and p-mTOR in cancer cells.
- Downregulates MMP-2, MMP-9, uPA, and uPAR mRNA levels in cancer cells.