Styrenes
eMolecules AstaTech / 4-METHOXY-4-NITROSTILBENE / 0.25g / 721754762 / D91422 / 95.000 / 1472-68-0 / MFCD00143335 / 255.273 / C15H13NO3
AstaTech / 4-METHOXY-4-NITROSTILBENE / 0.25g / 721754762 / D91422 / 95.000 / 1472-68-0 / MFCD00143335 / 255.273 / C15H13NO3
Apexbio Technology LLC CPI-637 1884712-47-3 10mg
CPI-637 (CAS 1884712-47-3) is a selective small molecule inhibitor targeting the bromodomains of CBP (CREB-binding protein) and EP300 with IC50 values of 0 03 M and 11 0 M respectively It demonstrates over 700-fold selectivity for CBP/EP300 bromodomains relative to the BET bromodomain family and displays significant selectivity over other bromodomain-containing proteins with notable biochemical activity observed only against BRD9 In cellular assays CPI-637 inhibits MYC expression with an EC50 of 0 60 M and effectively engages CBP in BRET assays (EC50 0 3 M) CPI-637 is currently utilized in preclinical research to investigate the role of CBP/EP300 bromodomains in transcriptional regulation and disease pathways
eMolecules 132465-11-3 | Medchem Express | Cinnamyl-34-dihydroxy--cyanocinnamate | 5mg | 596608155 | HY-138688 | MFCD00210839 | 321.332 | C19H15NO4
Ambeed | 26-Difluoro-3-methylphenylboronic acid | 100mg | 717401674 | A665657 | 1586045-40-0 | MFCD09265479 | 171.940 | C7H7BF2O2
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Medchemexpress LLC 8,11,14,17-eicosatetraenoic acid ethyl ester | 123940-93-2 | 98.0% | 332.52 g·mol⁻¹ | C22H36O2 | 500UG
Omega-3 arachidonic acid ethyl ester is the ethyl-ester derivative of arachidonic acid provided as a high-purity solution in ethanol for biochemical and lipid research applications. The material is characterized by CAS 123940-93-2, molecular formula C22H36O2, and molecular weight 332.52 g·mol⁻¹, and is supplied with recommended storage at -20°C.
Matrix Scientific 4-VINYLBENZOIC ACID-1G
4-Vinylbenzoic acid, 97%; 1g,C9H8O2, MFCD00002569, mw 148.16, [1075-49-6]
Sigma Aldrich Fine Chemicals Biosciences 1,6-Diphenyl-1,3,5-hexatriene 98% | 1720-32-7 | MFCD00004793 | 1G
1,6-Diphenyl-1,3,5-hexatriene 98% | Purity: 98% | Mol Wt: 232.32 | 1720-32-7 | MFCD00004793 | 1G
Medchemexpress LLC K858 (Racemic) | 72926-24-0 | 99.83% | 277.35 | 10 MM * 1 ML
K858 (Racemic) is an ATP-uncompetitive inhibitor of kinesin Eg5 with an IC50 of 1.3 μM. It is intended for research use only and is not sold to patients.
- Acts as an ATP-uncompetitive inhibitor of kinesin Eg5 (IC50 of 1.3 μM).
- Induces mitotic arrest and growth inhibition by activating the Mad2-mediated spindle checkpoint.
- Induces mitotic cell death in cancer cells but not in normal cells at 5 μM.
- Inhibits MCF7, BT474, and SKBR3 cell lines at 10 and 100 μM, and MDA-MB231 cell line at 10 and 100 μM after 24 hours.
- Increases Bax/Bcl2 RNA ratio and survivin in four cell lines.
- Upregulation of survivin is reversed by wortmannin (phosphoinositide 3-kinase AKT) in MCF7 cells.
- Shows antitumor activity in A2780 ovarian cancer xenograft and HCT116 colon cancer xenograft models.
- No neurotoxic side effects observed in mice at 100 mg/kg.