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Organic compounds that consist of a phenol ring with an amino functional group substitution; amino functional groups consist of a nitrogen atom bonded to hydrogen atoms via single bonds.
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MOG (35-55), human is a component of CNS myelin. It differs from mMOG (35-55) by a proline for serine substitution at position 42. This peptide is immunogenic via binding to H-2b class II MHC and is recognized by T cells, but it is not encephalitogenic. It shows only partial cross-reactivity with mMOG35-55 and induces minimal clinical signs of EAE compared to the rodent peptide.
Component of CNS myelin.
Immunogenic via binding to H-2b class II MHC.
Recognized by T cells.
Induces minimal clinical signs of EAE relative to the rodent peptide.
Not encephalitogenic.
Partially cross-reactive with mMOG35-55.
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