Aminophenols
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Medchemexpress LLC FTI-277 hydrochloride | 180977-34-8 | 98.0% | 484.07 | 5 MG
FTI-277 hydrochloride is an inhibitor of farnesyl transferase (FTase). It is a highly potent Ras CAAX peptidomimetic that antagonizes both H- and K-Ras oncogenic signaling and can inhibit hepatitis delta virus (HDV) infection.
- Inhibits farnesyl transferase (FTase)
- Antagonizes H- and K-Ras oncogenic signaling
- Can inhibit hepatitis delta virus (HDV) infection
- Significantly decreases survival of radioresistant cells expressing the 24-kDa isoform
- Stimulates postmitotic cell death in HeLa 3A cells
- Reduces G(2)/M-phase arrest in both cell types (HeLa 3A and HeLa PINA)
- Inhibits migration and invasion in PC-3 cells
- Prevents increased PTP-1B and PTEN protein expression in burned mice
