Cresols
![Medchemexpress LLC L-lysinamide, l-phenylalanyl-n-[4-(hydroxymethyl)phenyl]-n6-(triphenylmethyl)- | 1116085-99-4 | 96.2% | 640.81 g/mol | C41H44N4O3 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202975.png-250.jpg)
Medchemexpress LLC L-lysinamide, l-phenylalanyl-n-[4-(hydroxymethyl)phenyl]-n6-(triphenylmethyl)- | 1116085-99-4 | 96.2% | 640.81 g/mol | C41H44N4O3 | 10 MG
Phe-Lys(Trt)-PAB is a cathepsin-cleavable antibody-drug conjugate (ADC) linker used to build cleavable linker-payload constructs for research and development. It is a solid, Trt-protected dipeptide linked to a para-aminobenzyl (PAB) self-immolative spacer that is cleaved by lysosomal cathepsin proteases to enable payload release.
- Cathepsin-cleavable dipeptide linker.
- Trt-protected lysine side chain for orthogonal chemistry.
- Para-aminobenzyl (PAB) self-immolative spacer to enable payload release.
- High purity by LCMS (≈96.2%).
- White to off-white solid form.
- Molecular weight 640.81 g/mol; formula C41H44N4O3.
- Available in small milligram pack sizes suitable for research synthesis (for example, 10 mg).
Apexbio Technology LLC EZ Cap Mouse CD252(OX40L) mRNA (m1Ψ HA tag) 5x1mg (1mg/mL)
Mouse CD252 mRNA encodes cytokine OX40 ligand (OX40L) expressed on the surface of activated antigen-presenting cells such as dendritic cells B cells and macrophages Binding to the OX40 receptor (CD134) the CD252-OX40 signaling pathway plays a key role in the immune system promoting T cell proliferation survival and effector functions This signaling pathway significantly influences immune response regulation immune tolerance maintenance and anti-tumor immunity CD252 is involved in the pathological processes of autoimmune diseases and chronic inflammation EZ Cap Mouse CD252 (OX40L) mRNA (m1 HA tag) is provided at 1 mg/mL It expresses mouse-derived CD137 cytokine tagged with HA facilitating subsequent detection It contains a cap 1 structure generated via co-transcriptional capping Incorporation of modified nucleotides m1 along with a poly (A) tail minimizes RNA-induced innate immune activation and enhances mRNA stability and lifespan both in vitro and in vivo
Medchemexpress LLC IHMT-MST1-39 | 2414484-01-6 | 99.68% | 460.46 | 1 ML
IHMT-MST1-39 is an orally active inhibitor for MST kinase. It activates the AMPK signaling pathway in liver cells and reduces apoptosis of pancreatic β-cells, making it suitable for studies related to type 1 and type 2 diabetes.
- Blocks pancreatic β-cell apoptosis through MST1 inhibition
- Enhances pancreatic β-cell function and survival under diabetogenic conditions
- Activates AMPK signaling in HepG2 and HL7702 cells
- Reversed diabetic symptoms in a Streptozotocin (STZ)-induced T1D mouse model
- Prevented diabetic hyperglycemia in T2D mouse models
- Significantly reduced fasting blood glucose and improved glucose tolerance
- Lowered HbA1c levels and protected pancreatic islet structure and beta cell mass
- Improved glycemic control in spontaneous T2D models and HFD/STZ-induced T2D models
- Significantly improved insulin resistance
BIOHIPPO h/m FASN-sh-RFP/Luc
h/m FASN-sh-RFP/Luc shRNA lentiviral vector expressing RFP/Luc with selection for studies in Human/Mouse Each vial provides a nominal titer of 2x10E6 transducing units TU Validated h/m FASN shRNA Lentivirus High-titer shRNA lentiviral particles specific for human/mouse fatty acid synthase (FASN) The shRNA has been validated to meet or exceed 70% FASN knockdown efficiency using a specific fluorescence-based method that is more rapid and reliable than qPCR The shRNA lentivirus is ultra-purified and concentrated to high-titer by PEG precipitation and sucrose gradient centrifugation and ideal for transducing difficult-to-transfect cells including thawed and/or primary cells Order a shRNA lentivirus set and receive lentivirus produced from mix of 2 independent shRNAs validated to knockdown the target gene ( 70%) plus control lentivirus produced from mix of 2 scrambled shRNA constructs
