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Medchemexpress LLC IHMT-MST1-39 | 2414484-01-6 | 99.68% | 460.46 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY16459510MM/1ML

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IHMT-MST1-39 is an orally active inhibitor for MST kinase. It activates the AMPK signaling pathway in liver cells and reduces apoptosis of pancreatic β-cells, making it suitable for studies related to type 1 and type 2 diabetes.

  • Blocks pancreatic β-cell apoptosis through MST1 inhibition
  • Enhances pancreatic β-cell function and survival under diabetogenic conditions
  • Activates AMPK signaling in HepG2 and HL7702 cells
  • Reversed diabetic symptoms in a Streptozotocin (STZ)-induced T1D mouse model
  • Prevented diabetic hyperglycemia in T2D mouse models
  • Significantly reduced fasting blood glucose and improved glucose tolerance
  • Lowered HbA1c levels and protected pancreatic islet structure and beta cell mass
  • Improved glycemic control in spontaneous T2D models and HFD/STZ-induced T2D models
  • Significantly improved insulin resistance

Catalog No. 50-003-92066


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