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Filtered Search Results
Medchemexpress LLC 3,3-Dimethylacrylic acid | 541-47-9 | 99.99% | 100.12 | 50 G
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3,3-Dimethylacrylic acid is an active small molecule that can be used as a drug intermediate. It exhibits antituberculosis activity with a MIC of 0.078 μg/mL and can be used for the synthesis of triorganotin(IV) complexes of cinnamic acid. It is for research use only and not sold to patients. It has an appearance of a solid, white to off-white color. It is classified under Ketones, Aldehydes, Acids and its initial source is an endogenous metabolite.
- Exhibits antituberculosis activity with a MIC of 0.078 μg/mL.
- Can be used for the synthesis of triorganotin(IV) complexes of cinnamic acid.
- For research use only.
- Appearance: solid, white to off-white color.
- Classified under ketones, aldehydes, acids.
- Initial source is an endogenous metabolite.
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Medchemexpress LLC L-methioninamide hydrochloride | 16120-92-6 | MFCD00039084 | 99.2% | 184.69 g/mol | C5H13ClN2OS | 10 G
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L-methioninamide hydrochloride is the hydrochloride salt of L-methioninamide, a methionine analogue reported to inhibit methionyl-tRNA synthetase. It is supplied for research use and is available as solid material or as ready-to-use DMSO solutions for biochemical and biological studies.
- Acts as a methionyl-tRNA synthetase inhibitor.
- Available as solid and as 10 mM DMSO solution formats.
- High purity suitable for analytical and biological research.
- Molecular weight 184.69 g/mol; formula C5H13ClN2OS.
- For research use only; not for human or clinical use.
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Medchemexpress LLC Cyclophosphamide hydrate | 6055-19-2 | 99.9% | 500 MG
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Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. It induces outer membrane blebbing, leads to DNA fragmentation, and induces cleavage of caspase 3 and caspase 7 substrate PARP in 9L/P450 cells. In C3H mice bearing SW1 tumors, it increased the percentage of cells that stained for CD3, CD4, or CD8 in both spleens and tumors.
- Acts as a synthetic alkylating agent
- Exhibits antineoplastic and immunosuppressive activities
- Induces DNA fragmentation and caspase cleavage
- Increases immune cell markers in spleens and tumors
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Medchemexpress LLC HY-108593 10mg Medchemexpress, BMS-191011 CAS:202821-81-6 Purity:>98%
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Medchemexpress, HY-108593 10mg BMS-191011 CAS:202821-81-6 BMS-191011 (BMS-A) is an opener of the large-conductance, Ca2++-activated potassium (maxi-K) channel, effective in stroke models. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Apexbio Technology LLC Ro 106-9920 62645-28-7 10mg
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Ro 106-9920 (CAS 62645-28-7) is a small molecule inhibitor that selectively suppresses the activation of the NF-kappaB signaling pathway By interfering with NF-kappaB function Ro 106-9920 modulates transcriptional events involved in cellular inflammatory responses survival and tumor progression Aberrant NF-kappaB activity is frequently observed in various cancer cell types and is linked to enhanced proliferation invasion and resistance to apoptosis Ro 106-9920 is widely utilized in cellular and animal studies to investigate the roles of NF-kappaB in oncogenesis and related pathologies providing a valuable tool for elucidating NF-kappaB-mediated mechanisms and evaluating potential therapeutic strategies
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Apexbio Technology LLC HyperScript™ III First-Strand cDNA Synthesis Kit 50rxn
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HyperScript III First-Strand cDNA Synthesis Kit is an enzymatic reagent kit designed for generating first-strand complementary DNA (cDNA) from total RNA or poly(A) RNA templates It utilizes HyperScript III Reverse Transcriptase an engineered derivative of M-MLV reverse transcriptase with reduced RNase H activity and enhanced thermostability and fidelity HyperScript III First-Strand cDNA Synthesis Kit enables efficient synthesis of cDNA with extended length superior efficiency on GC-rich templates and compatibility with various primer types including random primers Oligo(dT) V/N and gene-specific primers Based on these features HyperScript III First-Strand cDNA Synthesis Kit is applicable for downstream applications such as PCR qPCR and gene expression analyses
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Medchemexpress LLC OS-3-106 | 10MG
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OS-3-106 is a potent BBB-penetrated and selective dopamine D3 receptor (D3R) agonist OS-3-106 binds with high affinity (Ki 0 2 nM) at the D3R OS-3-106 can be used for psychoactivator addiction research[1]
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eMolecules Ambeed / 6-Chloro-3-fluoropicolinonitrile / 100mg / 596329814 / A273736 / / 1207609-52-6 / MFCD18250470 / 156.540 / C6H2ClFN2
Ambeed / 6-Chloro-3-fluoropicolinonitrile / 100mg / 596329814 / A273736 / / 1207609-52-6 / MFCD18250470 / 156.540 / C6H2ClFN2
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Apexbio Technology LLC TC-H 106 937039-45-7 10mg
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TC-H 106 (CAS 937039-45-7) is a selective inhibitor of class I histone deacetylases (HDACs) targeting HDAC1 HDAC2 HDAC3 and HDAC8 with reported IC50 values of 150 nM 760 nM 370 nM and 5000 nM respectively By inhibiting HDAC activity TC-H 106 interferes with the removal of acetyl groups from histone lysine residues thereby modulating chromatin structure and gene expression In cellular assays TC-H 106 increases histone H3 acetylation in lymphoblastoid cells derived from Friedreich s ataxia (FRDA) patients and enhances frataxin mRNA levels in FRDA mouse models These findings highlight its application in studying epigenetic mechanisms and therapeutic approaches related to HDAC inhibition particularly in neurodegenerative disease models
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Ambeed 2R 3S 4R 5R 5 6Amino9Hpurin
(((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-2-(((hydroxy((hydroxy((R)-3-hydroxy-2,2-dimethyl-3-((2-((2-sulfanylethyl)carbamoyl)ethyl)carbamoyl)propoxy)phosphoryl)oxy)phosphoryl)oxy)methyl)oxolan-3-yl)oxy)phosphonic acid, 85-61-0, 85%
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Ambeed 4Hydroxyphenylboronic acid
4-Hydroxyphenylboronic acid, 71597-85-8, 97%
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Accela Chembio Inc 2 | 6-dichloro-7-methylpurine | 5g | 2273-93-0 | MFCD00039690 | 97+% | Shelf Life: 1440 Days | Light Sensitive
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2 | 6-dichloro-7-methylpurine | 5g | 2273-93-0 | MFCD00039690 | 97+% | Shelf Life: 1440 Days | Light Sensitive
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Medchemexpress LLC L-371,257 | 162042-44-6 | 99.3% | 507.58 | 10 MM / 1 ML
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L-371,257 is an orally bioavailable, non-blood-brain barrier penetrant, selective, and competitive antagonist of the oxytocin receptor (pA2=8.4). It exhibits high affinity at both the oxytocin receptor (Ki=19 nM) and vasopressin V1a receptor (Ki=3.7 nM).
- Orally bioavailable
- Non-blood-brain barrier penetrant
- Selective and competitive antagonist of the oxytocin receptor
- High affinity at oxytocin receptor (Ki=19 nM)
- High affinity at vasopressin V1a receptor (Ki=3.7 nM)
- Appears as a white to off-white solid
- Storage as powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
- Soluble in DMSO at 8.33 mg/mL (16.41 mM)
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Chemscene ChemScene | 2,6-Dichloro-7-methylpurine | 1G | CS-W002180 | 0.98 | 2273-93-0| MFCD00039690 | 203.032
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ChemScene | 2,6-Dichloro-7-methylpurine | 1G | CS-W002180 | 0.98 | 2273-93-0| MFCD00039690 | 203.032
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Medchemexpress LLC Envudeucitinibum | 2417135-66-9 | C22H18D6N6O3 | 1 ML
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Envudeucitinibum is a highly selective, allosteric, and orally active TYK2 inhibitor that binds to the JH2 domain of TYK2. It exhibits no off-target effects on other kinases (JAK1-3). It reduces signaling and the production of proinflammatory cytokines including IL-12, IL-23, IL-17, and type I interferons (IFNs). It can be utilized for research related to plaque psoriasis, systemic lupus erythematosus (SLE), and other immune-mediated diseases.
- Highly selective, allosteric, and orally active TYK2 inhibitor
- Binds to the JH2 domain of TYK2
- Exhibits no off-target effects on other kinases (JAK1-3)
- Reduces signaling and production of proinflammatory cytokines
- Potentially useful for research on immune-mediated diseases
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