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Filtered Search Results
Medchemexpress LLC Bis-NH2-PEG2 | 929-59-9 | 99.8% | 25 G
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Bis-NH2-PEG2 (PROTAC Linker 19) is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase and the other is for the target protein. They function by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Facilitates the degradation of target proteins via the ubiquitin-proteasome system
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Apexbio Technology LLC Lincomycin HCl 859-18-7 5g
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Lincomycin HCl (859-18-7) is a small-molecule inhibitor targeting bacterial protein synthesis It is designed to inhibit translation by binding to the 50S subunit of the bacterial ribosome thereby blocking peptide elongation Lincomycin HCl exerts its biological activity primarily through inhibition of bacterial protein synthesis In in vitro studies Lincomycin HCl demonstrates bacteriostatic activity with reported IC50 values ranging from approximately 0 5 g/mL to 2 g/mL depending on bacterial strain and culture conditions Based on these pharmacological properties Lincomycin HCl holds research potential in selective antibiotic assays bacterial resistance studies and maintenance of cell culture sterility
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Ambeed 1HInden2 3H one
1H-Inden-2(3H)-one, 615-13-4, 98%
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Apexbio Technology LLC Phenazopyridine HCl 136-40-3 10mM (in 1mL DMSO)
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Phenazopyridine HCl (CAS 136-40-3) is a small-molecule antagonist with competitive inhibitory activity (IC50 145 M) It exerts local analgesic effects primarily through topical action on the urinary tract mucosa thus alleviating pain symptoms associated with bladder and urethral irritation In experimental research phenazopyridine HCl is utilized in models investigating pain transmission pathways urinary tract epithelial responses and inflammatory modulation Based on these pharmacological properties phenazopyridine HCl holds research potential in the study of urinary tract inflammation epithelial permeability nerve differentiation and in assays evaluating analgesic activity in urological and neurobiological research
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TARGETMOL CHEMICALS INC MKT-077 10MG
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Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s 1.4-2.2 uM in vitro) through its ability to inhibit members of the Hsp70 family of molecular chaperones. purity: 98%
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Medchemexpress LLC 2-methylbutanal (2-methylbutyraldehyde) | 96-17-3 | MFCD00006984 | 98.6% | 86.13 g·mol⁻¹ | C5H10O | 50 G
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2-methylbutanal (2-methylbutyraldehyde) is a low-molecular-weight aldehyde (C5H10O, MW 86.13 g·mol⁻¹, CAS 96-17-3) supplied for analytical and research use. It is a volatile compound reported as a biomarker for detection of Proteus uropathogens and is commonly used as an analytical standard and reagent in flavor, fragrance, and biochemical studies.
- Volatile biomarker reported for detection of Proteus uropathogens
- Low molecular weight and high volatility suitable for headspace and GC analyses
- Reported purity 98.56% supporting analytical applications
- Available in multiple pack sizes, including 50 g, for laboratory use
- Formula C5H10O and molecular weight 86.13 g·mol⁻¹
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Medchemexpress LLC IL-33 Cynomolgus 100ug
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IL-33 Protein is a cytokine belonging to the IL-1 superfamily IL-33 induces helper T cells mast cells eosinophils and basophils to produce type 2 cytokines IL-33 acts intracellularly as a nuclear factor and extracellularly as a cytokine IL-33 mediates its biological effects via IL-1 receptor ST 2 activates NF-kappaB and MAP kinases and drives production of T(H)2-associated cytokines from in vitro polarized T(H)2 cells IL-33 Protein Cynomolgus is the recombinant cynomolgus-derived IL-33 protein expressed by E coli with tag free
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Apexbio Technology LLC Maprotiline HCl 10347-81-6 10mM (in 1mL DMSO)
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Maprotiline HCl (CAS 10347-81-6) is an orally administered selective norepinephrine reuptake inhibitor primarily investigated for its antidepressant properties Mechanistically Maprotiline modulates the extracellular signal-regulated kinase (ERK) pathway and interacts with cellular retinoic acid binding protein 1 (CRABP1) promoting apoptotic processes in cancer cells In preclinical studies Maprotiline has demonstrated the ability to induce cell death via these signaling mechanisms Additionally due to its effects on neuropathic pain modulation Maprotiline is utilized in research exploring chronic pain pathways and investigating pharmacological interventions for pain management
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Medchemexpress LLC 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline | 154057-56-4 | MFCD09031391 | 25g
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Pitavastatin impurity 1 is an impurity of Pitavastatin (HY-B0144A)
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Apexbio Technology LLC Cinacalcet HCl 364782-34-3 10mM (in 1mL DMSO)
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Cinacalcet HCl (CAS 364782-34-3) is a second-generation calcimimetic that acts as a potent allosteric modulator of the calcium-sensing receptor (CaSR) By enhancing the sensitivity of CaSR to extracellular calcium Cinacalcet HCl suppresses parathyroid hormone (PTH) secretion with an EC50 of 2 8 M reported in in vitro assays In preclinical models such as Rice H-500 tumor-bearing mice oral administration of Cinacalcet HCl significantly reduces blood ionized calcium total serum calcium and PTH-related peptide (PTHrP) levels Its ability to modulate mineral metabolism supports its use in research on disorders involving PTH dysregulation including secondary hyperparathyroidism and related mineral imbalances
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Medchemexpress LLC Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate | 64987-85-5 | MFCD00009634 | 99.6% | 334.32 g/mol | C16H18N2O6 | 100 G
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Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate is a heterobifunctional, non-cleavable crosslinker that couples primary amines to sulfhydryl groups via NHS-ester and maleimide chemistry. It is used to prepare stable protein-protein and protein-small molecule conjugates for applications such as antibody-drug conjugates and antigen conjugates for immunization.
- Heterobifunctional, non-cleavable crosslinker
- Reacts with primary amines (NHS ester) and sulfhydryls (maleimide)
- Used for protein conjugation and antibody-drug conjugate synthesis
- High purity suitable for research applications
- Store sealed, protect from moisture and light; recommended cold storage
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Apexbio Technology LLC 10058-F4 403811-55-2 10mM (in 1mL DMSO)
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10058-F4 (CAS 403811-55-2) is a small molecule inhibitor targeting the transcription factor c-Myc It disrupts the dimerization of c-Myc with Max thereby preventing the c-Myc/Max complex from binding to DNA This disruption impairs c-Myc-dependent transcriptional activity leading to inhibited proliferation and induction of apoptosis in leukemia cells as evidenced by Bcl-2 downregulation Bax upregulation and cytochrome c release 10058-F4 has also been shown to suppress growth factor-induced expression of PGC-1 implicating c-Myc in related transcriptional events Additionally in lymphoma cells it reduces c-Myc mRNA levels The compound is widely used in research to investigate c-Myc function in oncogenesis and cellular metabolism
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Apexbio Technology LLC HyperTrap Glutathione 4FF Column 5ml
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The HyperTrap Glutathione 4FF Column is a specialized affinity chromatography medium designed for the selective binding and purification of glutathione S-transferase (GST)-tagged proteins and glutathione-reactive biomolecules The column utilizes immobilized glutathione on a highly cross-linked 4FF agarose matrix enabling efficient capture of GST fusion proteins through specific glutathione-protein interactions This technology supports downstream applications such as protein purification functional characterization and interaction studies in molecular biology and biochemistry research The column s high binding capacity and stability make it suitable for preparative and analytical workflows requiring selective protein isolation
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Apexbio Technology LLC RNA Clean Beads(Synonyms: RNA purification beads, RNA magnetic beads, Magnetic RNA purification beads, RNA cleanup beads), 5ml.
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RNA Clean Beads are magnetic microparticles designed for rapid high-throughput RNA purification from DNase-treated samples The beads function through reversible nucleic acid binding RNA molecules from 100 bp to 50 kb bind selectively to the bead surfaces upon addition of binding solution allowing separation in a magnetic field Contaminants including DNA digestion fragments primer dimers salts and residual proteins are eliminated in subsequent washing steps RNA is then eluted using sterile water or elution buffer yielding purified RNA suitable for downstream enzymatic digestion sequencing hybridization and PCR analysis This product can integrate seamlessly into automated nucleic acid purification workflows
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Chemscene ChemScene | 3-Bromo-2-nitrophenol | 10G | CS-0042077 | 0.98 | 76361-99-4| MFCD08445675 | 218.006
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ChemScene | 3-Bromo-2-nitrophenol | 10G | CS-0042077 | 0.98 | 76361-99-4| MFCD08445675 | 218.006
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