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Filtered Search Results
eMolecules 558640-51-0 | Medchem Express | VER-49009 | 2mg | 446267106 | HY-15986 | 387.82 | C19H18ClN3O4
Medchem Express | VER-49009 | 2mg | 446267106 | HY-15986 | 558640-51-0 | 387.820 | C19H18ClN3O4
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Medchemexpress LLC STAT3-IN-15 | 3037596-35-0 | C20H17F3N2O3S | 1 ML
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STAT3-IN-15 is a potent and orally active STAT3 inhibitor effective against idiopathic pulmonary fibrosis (IPF). It inhibits STAT3 phosphorylation and also hinders the migration and deformation of epithelial cells induced by TGF-β1, consequently inhibiting epithelial-mesenchymal transition (EMT).
- Inhibits NIH-3T3 cell proliferation (IC50 of 0.47 μM).
- Forms hydrogen bonds with Lys591 and Ser636 in STAT3.
- Inhibits fibroblast activation and proliferation.
- Blocks TGF-β1 induced EMT process in A549 cells.
- Alleviates bleomycin-induced pulmonary fibrosis in mice.
- Recovers lung structure and reduces hydroxyproline content.
- Reduces p-Stat3Ty705 protein expression in lung tissue.
- Improves bleomycin-induced immune microenvironment imbalance.
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Apexbio Technology LLC Amitriptyline HCl 549-18-8 10mM (in 1mL DMSO)
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Amitriptyline HCl (CAS 549-18-8) is a tricyclic compound that modulates multiple neurotransmitter systems It acts as an inhibitor at serotonin and norepinephrine receptors demonstrating potent activity with IC50 values of 3 45 nM and 13 3 nM respectively Amitriptyline also exhibits notable affinity for 5-HT4 (IC50 7 31 nM) 5-HT2 (IC50 235 nM) and sigma-1 receptors (IC50 287 nM) indicating a broad spectrum of receptor interactions This pharmacological profile supports its application in neuropharmacological research including studies of synaptic transmission antidepressant mechanisms and receptor signaling pathways
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Aobchem AOBCHEM
5000865769 3-ETHOXY-5-FLUOROPHENOL 5G
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Aobchem AOBCHEM
5000865768 3-ETHOXY-5-FLUOROPHENOL 250MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000382305 QC-01 175 10MM 1ML
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Medchemexpress LLC C-82 | 1422253-37-9 | 99.9% | 578.66 | 1 MG
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C-82 is a second-generation specific CBP/β-catenin antagonist. It functions by inhibiting the binding between β-catenin and CBP, while simultaneously increasing the binding between β-catenin and p300. C-82 is the active form of PRI-724, which is rapidly hydrolyzed to C-82 in vivo and has shown an acceptable toxicity profile in preclinical studies.
- Inhibits CBP/β-catenin binding.
- Increases β-catenin/p300 binding.
- Inhibits activation of quiescent hepatic stellate cells (HSCs).
- Promotes cell death in culture-activated HSCs.
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Apexbio Technology LLC Eletriptan HBr 177834-92-3 10mM (in 1mL DMSO)
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Eletriptan hydrobromide (CAS 177834-92-3) is an orally bioavailable small molecule that acts as a selective agonist for the 5-hydroxytryptamine (serotonin) 5-HT1B and 5-HT1D receptors By activating these receptor subtypes eletriptan hydrobromide modulates cranial blood vessel tone and neuronal signaling implicated in migraine pathophysiology This compound is commonly utilized in preclinical and clinical research to investigate serotonergic modulation of neurovascular function and to explore therapeutic mechanisms relevant to migraine and related neurovascular disorders
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Alkali Scientific Kinetin [6 Furfurylaminopurine], 5 G
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Kinetin (6-Furfurylaminopurine) is a potent cytokinin used in plant tissue culture to induce cell division, promote shoot formation, and enhance plant regeneration. This 5g formulation is ideal for large-scale tissue culture applications where high concentrations of kinetin are required for efficient plant propagation and growth. Kinetin has been shown to delay the senescence of plant tissues and improve the overall vigor of regenerated plants. It is essential for enhancing regeneration rates in various plant species, making it a crucial tool in agriculture, horticulture, and plant biotechnology for improving crop yields and plant stress resistance.
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Medchemexpress LLC 1-Decanaminium, N,N-dimethyl-N-(3-sulfopropyl)-, inner salt | 15163-36-7 | 98.0% | 307.49 | 25 G
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Sulfobetaine 10 is a zwitterionic surfactant commonly used in biochemistry and biophysics. It is utilized to dissolve membrane proteins and other hydrophobic molecules in aqueous solutions. Its structure contains both positively and negatively charged groups, which allows it to maintain a neutral charge in solution and reduces its tendency to denature proteins. It is considered a mild, non-denaturing surfactant and is widely used in protein research. For research use only. We do not sell to patients.
- Zwitterionic surfactant
- Commonly used in biochemistry and biophysics
- Dissolves membrane proteins and other hydrophobic molecules in aqueous solutions
- Maintains a neutral charge in solution
- Reduces tendency to denature proteins
- Considered a mild, non-denaturing surfactant
- Widely used in protein research
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Cambridge Isotope Laboratories 2 2 4 6-TetraCB (unlabeled) 35 ug/mL in isooctane 1 mL
2 2 4 6-TetraCB (unlabeled) 35 ug/mL in isooctane 1 mL
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000377402 MARTINOSTAT HYDROCH 100MG
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Aobchem AOBCHEM
5000873417 1- 2- CYCLOBUTYLMETHOXY PHENYL
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eMolecules 1070-89-9 | Sodium bis(trimethylsilyl)amide 2M in THF | Oakwood Chemicals | MFCD00009835 | 183.377 | C6H18NNaSi2 | 0.000 | [Na+].C[Si](C)(C)[N-][Si](C)(C)C | 25g | 480171052
Sodium bis(trimethylsilyl)amide 2M in THF | Oakwood Chemicals | 1070-89-9 | MFCD00009835 | 183.377 | C6H18NNaSi2 | 0.000 | [Na+].C[Si](C)(C)[N-][Si](C)(C)C | 25g | 480171052
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000596543 RAPIROSIRAN SODIUM 1MG
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