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Filtered Search Results
Apexbio Technology LLC Nepicastat (SYN-117) HCl 170151-24-3 50mg
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Nepicastat (SYN-117) HCl is a potent and selective inhibitor targeting dopamine -hydroxylase (DBH) an enzyme responsible for converting dopamine to norepinephrine in catecholamine biosynthesis pathways By inhibiting DBH activity Nepicastat decreases norepinephrine synthesis and concurrently elevates dopamine levels Preclinical studies conducted in animal models such as spontaneously hypertensive rats and canine models demonstrate a dose-dependent reduction of norepinephrine levels accompanied by elevation of dopamine concentration across central nervous system and cardiac tissues Nepicastat serves as a valuable research tool in investigating catecholamine homeostasis cardiovascular function sympathetic regulation and dopamine-mediated neurotransmission
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eMolecules Ambeed / 4-Bromo-26-dichlorophenol / 1g / 525009544 / A115050 / / 3217-15-0 / MFCD00019996 / 241.890 / C6H3BrCl2O
Ambeed / 4-Bromo-26-dichlorophenol / 1g / 525009544 / A115050 / / 3217-15-0 / MFCD00019996 / 241.890 / C6H3BrCl2O
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Medchemexpress LLC F-15599 | 635323-95-4 | 99.1% | 394.85 | 1 ML
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F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist with a Ki of 3.4 nM, intended for research use. It has been shown to significantly reduce l-DOPA-induced dyskinesia (LID) without affecting motor performance, and to cause a dose-dependent delay in attack latency, reducing aggressive behavior in rats.
- Acts as a highly selective G-protein biased 5-HT1A receptor agonist.
- Reduces l-DOPA-induced dyskinesia (LID).
- Decreases aggressive behavior.
- Increases discharge rate of pyramidal neurons in the medial prefrontal cortex (mPFC).
- Modulates dopamine and serotonin release.
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Medchemexpress LLC Dichlorophenylindophenol sodium | 620-45-1 | MFCD00012176 | 98.0% | 5 G
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DCIP sodium is a blue dye commonly used in various biochemical and biotechnological applications as an indicator of redox reactions. It possesses unique chemical properties that cause its color to change based on the oxidation state of the tested substance. It is frequently employed in enzyme assays, such as measuring succinate dehydrogenase activity, and in protein quantification methods like the Lowry assay.
- Biochemical reagent.
- Can be used as a biological material or organic compound for life science related research.
- Blue dye that changes color according to the oxidation state of the substance being tested.
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eMolecules Oakwood Chemicals Saturated aqueous Sodium bicarbonate solution ( 9 6% wt/wt) 1kg 480155352 104315 0 000 144-55-8 MFCD00003528 84 006 CHNaO3
Oakwood Chemicals Saturated aqueous Sodium bicarbonate solution ( 9 6% wt/wt) 1kg 480155352 104315 0 000 144-55-8 MFCD00003528 84 006 CHNaO3
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Medchemexpress LLC Benzenepropanol | 122-97-4 | 99.8% | 136.19 | 250 G
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Benzenepropanol is a biochemical reagent suitable for life science related research. It is intended for research use only and not for patient use. This product is provided as a liquid with a density of 1.001 g/cm3, typically colorless to light yellow.
- High purity of 99.76%
- Available in various quantities for research needs
- Can be stored at -20°C for 3 years in pure form
- Soluble in DMSO for in vitro applications
- Multiple in vivo dissolution methods available
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Medchemexpress LLC Amantadine | 768-94-5 | 99.9% | 25 G
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Amantadine (1-Adamantanamine) is an orally active and potent antiviral agent primarily effective against influenza A viruses. It functions by inhibiting several ion channels, including NMDA and M2, and also affects Coronavirus ion channels. Beyond its antiviral properties, Amantadine exhibits anti-orthopoxvirus and anticancer activities. It is utilized in research for Parkinson's disease, postoperative cognitive dysfunction (POCD), and COVID-19.
- Potent antiviral agent against influenza A viruses
- Inhibits multiple ion channels including NMDA and M2
- Exhibits anti-orthopoxvirus and anticancer activity
- Used in research for Parkinson's disease
- Researched for postoperative cognitive dysfunction (POCD) and COVID-19
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Medchemexpress LLC (R)-BPO-27 | 1415390-47-4 | 99.9% | 548.34 | 1 ML
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(R)-BPO-27 is a potent, orally active, and ATP-competitive CFTR inhibitor with an IC50 of 4 nM. It is the R enantiomer of BPO-27, acting from the cytoplasmic side with low membrane permeability. This compound reduces channel open probability and increases mean channel closed time in HEK-293T cells expressing human wild-type CFTR, and is intended for research use only.
- Potent CFTR inhibitor with an IC50 of 4 nM
- Stabilizes CFTR channel closed state at 600 pM
- Effective in inhibiting Cl- current stimulated by cAMP and cGMP agonists
- Provides sustained therapeutic concentrations in the kidney
- Prevents cholera toxin-induced fluid accumulation in intestinal loops
- Achieves approximately 94% oral bioavailability in mice
- Exhibits slow metabolism, maintaining serum levels for over 4 hours
- Shows efficacy in mouse models of cholera and traveler's diarrhea
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Medchemexpress LLC Fondaparinux sodium | 114870-03-0 | 98.0% | 1 ML
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Fondaparinux sodium is an antithrombin-dependent factor Xa inhibitor intended for research use only. This compound exhibits high purity and is available as a white to off-white solid.
- Antithrombin-dependent factor Xa inhibitor
- For research use only
- High purity of 98.0%
- Appears as a white to off-white solid
- Soluble in H2O
- Exhibits a linear, dose-dependent pharmacokinetic profile
- Features 100% bioavailability, rapid onset of action, and a half-life of 14 to 16 hours
- Does not affect prothrombin time, activated partial thromboplastin time, platelet function, or aggregation
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Medchemexpress LLC Fondaparinux sodium | 114870-03-0 | 98.0% | 1 MG
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Fondaparinux sodium is an antithrombin-dependent factor Xa inhibitor and the first agent of a new class of anticoagulants that selectively targets factor Xa.
- Antithrombin-dependent factor Xa inhibitor
- First agent of a new class of anticoagulants
- Selectively targets factor Xa
- Purity: 98.0%
- Molecular weight: 1728.08
- Appearance: Solid, white to off-white
- Solubility: 125 mg/mL (72.33 mM) in H2O (requires ultrasonic)
- Shows a linear, dose-dependent pharmacokinetic profile with 100% bioavailability
- Rapid onset of action with a half-life of 14 to 16 hours
- Does not affect prothrombin time, activated partial thromboplastin time, platelet function, or aggregation
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Medchemexpress LLC GSK 3008348 hydrochloride | 1629249-40-6 | 99.9% | 524.11 | 50 MG
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GSK 3008348 hydrochloride is a small molecule antagonist of integrin αvβ6. It targets the αvβ6 integrin, inhibits TGF-β activation, and can alleviate the fibrotic process. It also prevents the binding of the foot-and-mouth disease virus (FMDV) to the αvβ6 integrin receptor, inhibiting virus entry. GSK 3008348 hydrochloride can be used for research on pulmonary fibrosis and various types of cancer.
- Small molecule antagonist of integrin αvβ6.
- Inhibits TGF-β activation.
- Alleviates the fibrotic process.
- Prevents binding of foot-and-mouth disease virus (FMDV) to the αvβ6 integrin receptor.
- Inhibits viral entry.
- Used for research on pulmonary fibrosis and various types of cancer.
- Antagonizes integrin αvβ6 with high affinity.
- Suppresses FMDV RNA replication and virus production.
- Decreases TGF-β1-activated procollagen I production.
- Inhibits TGF-β-induced phosphorylation of ERK1/2 and STAT3.
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Medchemexpress LLC Fluorenone | 486-25-9 | 99.98% | 180.20 | 500 G
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Fluorenone (9H-fluoren-9-one) is a biochemical reagent used as a biological material or organic compound for life science-related research. It is intended for research use only and can serve as an intermediate for organic synthesis.
- Biochemical reagent
- Organic compound for life science research
- Suitable for organic synthesis
- Solid appearance
- Light yellow to yellow color
- Soluble in DMSO
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eMolecules Combi-Blocks Sodium chlorodifluoroacetate 1kg 350780141 QA-3051 98 000 1895-39-2 MFCD00064771 152 460 C2ClF2NaO2
Combi-Blocks Sodium chlorodifluoroacetate 1kg 350780141 QA-3051 98 000 1895-39-2 MFCD00064771 152 460 C2ClF2NaO2
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eMolecules Chem-Impex N-Bromosuccinimide 1kg 112443016 02285 0 000 128-08-5 MFCD00005510 177 985 C4H4BrNO2
Chem-Impex N-Bromosuccinimide 1kg 112443016 02285 0 000 128-08-5 MFCD00005510 177 985 C4H4BrNO2
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eMolecules Chem-Impex 2-Bromo-4-fluorophenol 1kg 205002391 25759 0 000 496-69-5 MFCD00010614 190 999 C6H4BrFO
Chem-Impex 2-Bromo-4-fluorophenol 1kg 205002391 25759 0 000 496-69-5 MFCD00010614 190 999 C6H4BrFO
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