Carboxylic acid esters
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eMolecules Medchem Express / FMK / 2mg / 446271308 / HY-52101A / / 821794-92-7 / MFCD22417081 / 342.374 / C18H19FN4O2
Medchem Express / FMK / 2mg / 446271308 / HY-52101A / / 821794-92-7 / MFCD22417081 / 342.374 / C18H19FN4O2
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Medchemexpress LLC Neratinib (maleate) | 915942-22-2 | 99.7% | 673.11 | 1 ML
Neratinib (HKI-272) maleate is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively. This product is for research use only.
- Inhibits HER2 and EGFR with IC50s of 59 nM and 92 nM.
- Shows anticancer activities against cancer cells expressing high levels of HER-2 or EGFR.
- Reduces tumor growth in a dose-dependent manner in various xenografts.
- Inhibits proliferation of cell lines with high HER-2 levels.
- Arrests cell cycle at G1-S phase in BT474 cells.
- Inhibits MAPK and Akt phosphorylation.
- Down-regulates cyclin D1 levels and induces p27.
- Inactive in MX-1 and MCF-7 xenografts.
- Inhibited phosphorylation of HER-2 in BT474 xenografts.