Tricarboxylic acids and derivatives
Medchemexpress LLC DMAPP (triammonium) | 1186-30-7 | 95.0% | 1 MG
DMAPP (Dimethylallyl diphosphate) triammonium is an isoprenoid precursor found in virtually all life forms. It is an isomer of isopentenyl pyrophosphate (IPP) and plays a role in both the mevalonate and MEP pathways of isoprenoid precursor biosynthesis. The enzyme isopentenyl pyrophosphate isomerase catalyzes the isomerization between DMAPP and IPP.
- Isoprenoid precursor
- Isomer of isopentenyl pyrophosphate (IPP)
- Found in virtually all life forms
- Product of mevalonate and MEP pathways
- Involved in isoprenoid precursor biosynthesis
- Isomerization catalyzed by isopentenyl pyrophosphate isomerase
Medchemexpress LLC Clomiphene citrate | 50-41-9 | 98.2% | 1 ML
Clomiphene citrate is an orally active estrogen-receptor modulator. It has anti-cancer activity, induces perturbations during meiotic maturation and cytogenetic abnormalities, and aids in managing psychiatric and cognitive impairment.
- Inhibits viability of PC3 human prostate cancer cells
- Induces chromosome abnormalities in mouse oocytes
- Demonstrates anxiolytic potential
- Improves cognitive functions in letrozole-induced polycystic ovary syndrome (PCOS) rats
- Raises NRF-2 gene expression
- Down-regulates acetylcholine esterase expression
Medchemexpress LLC 5,8,11,14,17,20-hexaoxa-2-azadocosanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester | 437655-96-4 | MFCD26142983 | 99.4% | 561.62 g/mol | C29H39NO10 | 50 MG
Fmoc-NH-PEG6-CH2COOH is an Fmoc-protected PEG6 linker bearing a terminal carboxylic acid and an Fmoc-protected amine. It is used as a hydrophilic spacer in the synthesis of proteolysis targeting chimeras (PROTACs) and antibody-drug conjugates (ADCs), providing solubility and a reactive handle for amide coupling.
- Fmoc-protected amine for orthogonal protection in synthesis.
- Terminal carboxylic acid suitable for amide coupling.
- PEG6 spacer increases hydrophilicity and solubility.
- High reported purity (≈99.4%).
- Available in multiple package sizes for milligram to gram scale work.
Medchemexpress LLC Sparfosic acid trisodium | 70962-66-2 | 98.0% | 321.06 | 50 MG
Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase, an enzyme that catalyzes the second step of de novo pyrimidine biosynthesis. It synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines. It is for research use only.
- DNA antimetabolite agent
- Potent inhibitor of aspartate transcarbamoyl transferase
- Synergistically enhances the cytotoxicity of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines
- Causes apoptosis in resistant Br1 cells
- Leads to progressive accumulation of cells in S phase and activation of an apoptotic pathway at 300 μM
- Increases lifespan in mice bearing B16 melanoma
- Curative in 50% of mice with Lewis lung carcinoma when treated on days 1, 5, and 9 following s.c. implantation