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Medchemexpress LLC Sparfosic acid trisodium | 70962-66-2 | 98.0% | 321.06 | 50 MG
Supplier: Medchemexpress LLC HY112732B50MG
Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase, an enzyme that catalyzes the second step of de novo pyrimidine biosynthesis. It synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines. It is for research use only.
- DNA antimetabolite agent
- Potent inhibitor of aspartate transcarbamoyl transferase
- Synergistically enhances the cytotoxicity of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines
- Causes apoptosis in resistant Br1 cells
- Leads to progressive accumulation of cells in S phase and activation of an apoptotic pathway at 300 μM
- Increases lifespan in mice bearing B16 melanoma
- Curative in 50% of mice with Lewis lung carcinoma when treated on days 1, 5, and 9 following s.c. implantation
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